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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 550 - 575
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4673
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    14
    0
    Sugar
    43 percent target mRNA inhibition
    US 20080249039 A1
    SM4674
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    15
    0
    Sugar
    85 percent target mRNA inhibition
    US 20080249039 A1
    SM4675
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    16
    0
    Sugar
    81 percent target mRNA inhibition
    US 20080249039 A1
    SM4676
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    17
    0
    Sugar
    93 percent target mRNA inhibition
    US 20080249039 A1
    SM4677
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    18
    0
    Sugar
    92 percent target mRNA inhibition
    US 20080249039 A1
    SM4678
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    19
    0
    Sugar
    88 percent target mRNA inhibition
    US 20080249039 A1
    SM4710
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,2,13,14
    0
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4711
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,2
    0
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4713
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,20, 21
    0
    Sugar
    8 percent target mRNA inhibition
    EP2548962A1
    SM4715
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,2,13,14
    0
    Sugar
    51 percent target mRNA inhibition
    EP2548962A1
    SM4716
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,2
    0
    Sugar
    35 percent target mRNA inhibition
    EP2548962A1
    SM4718
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    0
    Locked nucleic acid
    0
    1,20, 21
    0
    Sugar
    35 percent target mRNA inhibition
    EP2548962A1
    SM4746
    CAUUGGUGAAGGAUCCAGGA
    UCCUGGAUCCUUCACCAAUG
    0
    2-O-Methylribose
    0
    6,12,15,18,19,20
    0
    Sugar
    IC-50 = 0.022859 nM for target mRNA
    US 8394947 B2
    SM4747
    CAUUGGUGAAGGAUCCAGGA
    CCUGGAUCCUUCACCAAUG
    0
    2-O-Methylribose
    0
    5,6,9,10,17,18,19
    0
    Sugar
    IC-50 = 0.01205 nM for target mRNA
    US 8394947 B2
    SM4748
    AGAAGACACCUUCUGAGUAU
    AUACUCAGAAGGUGUCUUCU
    0
    2-O-Methylribose
    0
    6,7,10,11,18,19,20
    0
    Sugar
    IC-50 = 0.075517 nM for target mRNA
    US 8394947 B2
    SM4749
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    2-O-Methylribose
    0
    5,8,11,14,17,18,19
    0
    Sugar
    IC-50 = 0.17024 nM for target mRNA
    US 8394947 B2
    SM4750
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    2-O-Methylribose
    0
    6,7,10,11,17,18,19
    0
    Sugar
    IC-50 = 0.055386 nM for target mRNA
    US 8394947 B2
    SM4760
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.809 nM for target mRNA
    US 8394947 B2
    SM4761
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    4-Thioribose* Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 6,7,8
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.57 nM for target mRNA
    US 8394947 B2
    SM4762
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Locked nucleic acid
    0
    1,2,3,6,9,12,15,18,19,20
    0
    Sugar
    IC-50 = 0.769 nM for target mRNA
    US 8394947 B2
    SM4763
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Locked nucleic acid* Phosphorothioate
    0
    1,2,3 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar; Phosphate-linkage
    IC-50 = 18.4 nM for target mRNA
    US 8394947 B2
    SM4764
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Locked nucleic acid* Phosphorothioate
    0
    4,9,19 * 4,9,19
    0
    Sugar; Phosphate-linkage
    IC-50 = 0.020825 nM for target mRNA
    US 8394947 B2
    SM4765
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.5627 nM for target mRNA
    US 8394947 B2
    SM4766
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 18,19,20
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.27688 nM for target mRNA
    US 8394947 B2
    SM4767
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 19
    0
    Phosphate-linkage; Sugar
    IC-50 = 5.58 nM for target mRNA
    US 8394947 B2