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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxyribonucleotide are 17
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2495
    CUCCUUTTGTTTCTGCUAACG
    CGTTUGCAGAAACAAUUGGUG
    2-Deoxyribonucleotide
    0
    7,8,9,10,11,12,13,14,15
    0
    Sugar
    0
    High target mRNA inhibition efficacy
    12771197
    SM2507
    CGAGGGGAGUACAUCAAGACC
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2508
    CGAGGGGAGUACAUCAAGATT
    UCUUGAUGUACUCCCCUCGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM4427
    GGCCUUUCACUACUCCUACTT
    GUAGGAGUAGUGAAAGGCCTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    36 percent target mRNA inhibition
    21141919
    SM4434
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    45 percent target mRNA inhibition
    21141919
    SM4437
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    2-Deoxyribonucleotide
    [1,1-Biphenyl]-3,5-dimethanol* 2-Deoxyribonucleotide
    20,21
    1 * 21,22
    Base
    Base
    34 percent target mRNA inhibition
    21141919
    SM4438
    CUUCUUCGUCGAGACCAUGTT
    CAUGGUCUCGACGAAGAAGTT
    2-Deoxyribonucleotide
    [3-(hydroxymethyl)-5-naphthalen-1-ylphenyl]methanol* 2-Deoxyribonucleotide
    20,21
    1 * 21,22
    Base
    Base
    25 percent target mRNA inhibition
    21141919
    SM4439
    UUUCACUACUCCUACGAGCTT
    GCUCGUAGGAGUAGUGAAATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    0 percent target mRNA inhibition
    21141919
    SM4443
    UAAGAUGUUCAUCGAGUCCTT
    GGACUCGAUGAACAUCUUATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Base
    Base
    0 percent target mRNA inhibition
    21141919
    SM4446
    GUCUCGUAGACCGUGCAUCATT
    UGAUGCACGGUCUACGAGACTT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    21,22
    20,21
    Base
    Base
    NA
    21141919
    SM4462
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    54 percent target mRNA inhibition
    21985606
    SM4468
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    25 percent target mRNA inhibition
    21985606
    SM4474
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4480
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4534
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    0
    24,25
    0
    Sugar
    0
    70 percent target mRNA inhibition
    22236254
    SM4536
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    1-Aminohexane
    24,25
    27
    Sugar
    Phosphate
    53 percent target mRNA inhibition
    22236254
    SM4538
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    1-Aminohexane
    24,25
    1
    Sugar
    Phosphate
    78 percent target mRNA inhibition
    22236254