Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 4-Thioribose are 72
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2275
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    0
    4,10,11,17
    0
    Sugar
    0
    IC-50 = 1.1 nM for target mRNA
    16509579
    SM2276
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    0
    1,2,18,19
    0
    Sugar
    0
    IC-50 = 0.28 nM for target mRNA
    16509579
    SM2277
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    Phosphorothioate
    4,10,11,17
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
    Sugar
    Phosphate
    IC-50 = 2.4 nM for target mRNA
    16509579
    SM2278
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    Phosphorothioate
    1,2,18,19
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
    Sugar
    Phosphate
    IC-50 = 1.4 nM for target mRNA
    16509579
    SM2279
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose
    4,10,11,17
    1,2,18,19
    Sugar
    Sugar
    IC-50 = 1.7 nM for target mRNA
    16509579
    SM2280
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose
    1,2,18,19
    1,2,18,19
    Sugar
    Sugar
    IC-50 = 0.21 nM for target mRNA
    16509579
    SM2285
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose* 2-O-Methyl
    4,10,11,17
    1,2 * 17,18,19
    Sugar
    Sugar
    IC-50 = 1.9 nM for target mRNA
    16509579
    SM2286
    AAGUAAGGACCAGAGACAA
    UUGUCUCUGGUCCUUACUU
    4-Thioribose
    4-Thioribose* 2-O-Methyl
    1,2,18,19
    1,2 * 17,18,19
    Sugar
    Sugar
    IC-50 = 0.15 nM for target mRNA
    16509579
    SM4857
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    3,12,15,16
    0
    Sugar
    0
    96.3 percent target mRNA inhibition
    15919084
    SM4858
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,5,7,14,17
    0
    Sugar
    0
    93.6 percent target mRNA inhibition
    15919084
    SM4859
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,3,5,7,12,14,15,16,17
    0
    Sugar
    0
    92.9 percent target mRNA inhibition (IC-50 = 0.12 nM)
    15919084
    SM4860
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    60.3 percent target mRNA inhibition
    15919084
    SM4865
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6
    0
    Sugar
    0
    94 percent target mRNA inhibition
    15919084
    SM4866
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    14,15,16,17,18,19
    0
    Sugar
    0
    93.8 percent target mRNA inhibition
    15919084
    SM4867
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    7,8,9,10,11,12,13
    0
    Sugar
    0
    87.4 percent target mRNA inhibition (IC-50 = 0.31 nM)
    15919084
    SM4868
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    91.5 percent target mRNA inhibition (IC-50 = 0.16 nM)
    15919084
    SM4878
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2
    0
    Sugar
    0
    95.5 percent target mRNA inhibition
    17150641
    SM4879
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    94.2 percent target mRNA inhibition
    17150641
    SM4880
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,16,17,18,19
    0
    Sugar
    0
    94.7 percent target mRNA inhibition
    17150641
    SM4883
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2
    18,19
    Sugar
    Sugar
    91.3 percent target mRNA inhibition
    17150641
    SM4884
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    16,17,18,19
    Sugar
    Sugar
    86.1 percent target mRNA inhibition
    17150641
    SM4886
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2
    0
    Sugar
    0
    69.5 percent target mRNA inhibition
    17150641
    SM4887
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    70.4 percent target mRNA inhibition
    17150641
    SM4888
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4,16,17,18,19
    0
    Sugar
    0
    79.1 percent target mRNA inhibition
    17150641
    SM4891
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2
    18,19
    Sugar
    Sugar
    72.4 percent target mRNA inhibition
    17150641