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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 350 - 375
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2678
    CUAAGGACCUAACAAAGUUUU
    AACUUUGUUAGGUCCUUAGUU
    Locked nucleic acid
    0
    1
    0
    Sugar
    0
    64 percent target mRNA inhibition
    20005874
    SM2909
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2910
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2917
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2918
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2925
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2926
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2933
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM2934
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    21687525
    SM3015
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    22287630
    SM3046
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    0
    20,21
    0
    Sugar
    0
    97 percent target mRNA inhibition
    15653644
    SM3047
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3053
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    27 percent target mRNA inhibition
    15653644
    SM3057
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3058
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3060
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    52 percent target mRNA inhibition
    15653644
    SM3061
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    1,20,21
    Sugar
    Sugar
    65 percent target mRNA inhibition
    15653644
    SM3062
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    74 percent target mRNA inhibition
    15653644
    SM3063
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,3,5,9,12,14,17,20,21
    0
    Sugar
    0
    68 percent target mRNA inhibition
    15653644
    SM3065
    TGAGAGAAAGCACAGAAAATT
    TUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    1,20,21
    Sugar
    Sugar
    67 percent target mRNA inhibition
    15653644
    SM3066
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    82 percent target mRNA inhibition
    15653644
    SM3067
    TCCAGAACAAAGGAAACGGTT
    CCGUUUCCUUUGUUCUGGATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    50 percent target mRNA inhibition
    15653644
    SM3068
    GGAUGAGGAAGGCAAUUUATT
    UAAAUUGCCUUCCUCAUCCTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    50 percent target mRNA inhibition
    15653644
    SM3070
    ACUGUCAAACCCGGUAAUUTT
    AAUUACCGGGUUUGACAGUTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    52 percent target mRNA inhibition
    15653644
    SM3343
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Locked nucleic acid
    Locked nucleic acid
    21
    1
    Sugar
    Sugar
    NA
    12834349