Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 250 - 275
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2956
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    4
    0
    Sugar
    94 percent target mRNA inhibition (IC-50 = 0.13 nM)
    19917641
    SM2957
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    5
    0
    Sugar
    92 percent target mRNA inhibition (IC-50 = 0.21 nM)
    19917641
    SM2958
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    6
    0
    Sugar
    78 percent target mRNA inhibition (IC-50 = 0.23 nM)
    19917641
    SM2959
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    7
    0
    Sugar
    86 percent target mRNA inhibition (IC-50 = 0.39 nM)
    19917641
    SM2960
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    8
    0
    Sugar
    90 percent target mRNA inhibition (IC-50 = 0.15 nM)
    19917641
    SM2961
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    9
    0
    Sugar
    89 percent target mRNA inhibition (IC-50 = 2.31 nM)
    19917641
    SM2962
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    10
    0
    Sugar
    23 percent target mRNA inhibition
    19917641
    SM2963
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    11
    0
    Sugar
    0 percent target mRNA inhibition
    19917641
    SM2964
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    12
    0
    Sugar
    59 percent target mRNA inhibition (IC-50 = 6.78 nM)
    19917641
    SM2965
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    13
    0
    Sugar
    74 percent target mRNA inhibition (IC-50 = 2.17 nM)
    19917641
    SM2966
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    14
    0
    Sugar
    64 percent target mRNA inhibition (IC-50 = 3.09 nM)
    19917641
    SM2967
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    15
    0
    Sugar
    86 percent target mRNA inhibition (IC-50 = 0.76 nM)
    19917641
    SM2968
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    16
    0
    Sugar
    29 percent target mRNA inhibition
    19917641
    SM2969
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    17
    0
    Sugar
    87 percent target mRNA inhibition (IC-50 = 1.29 nM)
    19917641
    SM2970
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    18
    0
    Sugar
    91 percent target mRNA inhibition (IC-50 = 1.02 nM)
    19917641
    SM2971
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    19
    0
    Sugar
    82 percent target mRNA inhibition (IC-50 = 1.20 nM)
    19917641
    SM2972
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    20,21
    0
    Sugar
    81 percent target mRNA inhibition (IC-50 = 0.56 nM)
    19917641
    SM2973
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    1
    0
    Sugar
    87 percent target mRNA inhibition (IC-50 = 0.26 nM)
    19917641
    SM2974
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    2
    0
    Sugar
    2 percent target mRNA inhibition
    19917641
    SM2975
    GUAUGACCGACUACGCGUATT
    UUCAGUGUGAUGACACUUGTT
    0
    Unlocked nucleic acid
    0
    3
    0
    Sugar
    50 percent target mRNA inhibition (IC-50 = 4.95 nM)
    19917641
    SM2977
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro
    0
    1,2,3,11,12,14,16,17,19
    0
    Sugar
    83 percent target mRNA inhibition
    12923253
    SM2980
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* 2-Deoxy
    0
    1,2,3,11,12,14,16,17,19 * 9,10,13
    0
    Sugar
    85 percent target mRNA inhibition
    12923253
    SM2982
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* 2-Deoxy
    0
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    0
    Sugar
    42 percent target mRNA inhibition
    12923253
    SM2984
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2987
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    16 percent target mRNA inhibition
    12923253