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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 300 - 325
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3075
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    6,20,21
    0
    Sugar
    85 percent target mRNA inhibition
    15653644
    SM3076
    CUUACGCUGAGUACUUCGATT
    TCGAAGTACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    7,20,21
    0
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3077
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    8,20,21
    0
    Sugar
    90 percent target mRNA inhibition
    15653644
    SM3078
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid* Methylcytosine
    0
    9,20,21 * 1
    0
    Sugar
    91 percent target mRNA inhibition
    15653644
    SM3079
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACTCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    10,20,21
    0
    Sugar
    60 percent target mRNA inhibition
    15653644
    SM3080
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid* Methylcytosine
    0
    11,20,21 * 1
    0
    Sugar
    92 percent target mRNA inhibition
    15653644
    SM3081
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    12,20,21
    0
    Sugar
    70 percent target mRNA inhibition
    15653644
    SM3082
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    12,20,21
    0
    Sugar
    94 percent target mRNA inhibition
    15653644
    SM3083
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid* Methylcytosine
    0
    14,20,21 * 1
    0
    Sugar
    56 percent target mRNA inhibition
    15653644
    SM3084
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    15,20,21
    0
    Sugar
    87 percent target mRNA inhibition
    15653644
    SM3085
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGTAAGTT
    0
    Locked nucleic acid
    0
    16,20,21
    0
    Sugar
    83 percent target mRNA inhibition
    15653644
    SM3086
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    17,20,21
    0
    Sugar
    96 percent target mRNA inhibition
    15653644
    SM3087
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    18,20,21
    0
    Sugar
    95 percent target mRNA inhibition
    15653644
    SM3088
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    0
    Locked nucleic acid
    0
    19,20,21
    0
    Sugar
    92 percent target mRNA inhibition
    15653644
    SM3093
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    13
    0
    Sugar
    IC-50 = 0.17 nM for target mRNA
    17284457
    SM3094
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACTUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    13
    0
    Sugar
    IC-50 = 0.31 nM for target mRNA
    17284457
    SM3095
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 3.6 nM for target mRNA
    17284457
    SM3096
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 0.16 nM for target mRNA
    17284457
    SM3097
    GCUUGAAGUCUUUAAUUAATT
    TTAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 1 nM for target mRNA
    17284457
    SM3098
    GCUUGAAGUCUUUAAUUAATT
    TTAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 0.04 nM for target mRNA
    17284457
    SM3111
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    0
    2,4-Difluorobenzene
    0
    7
    0
    Base
    90 percent target mRNA inhibition
    18624291
    SM3112
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    0
    2,3-Di-Chlorobenzene
    0
    7
    0
    Base
    92 percent target mRNA inhibition
    18624291
    SM3113
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    0
    2,3-Di-Chlorobenzene
    0
    7
    0
    Base
    58 percent target mRNA inhibition
    18624291
    SM3114
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    0
    4-Methylbenzimidazole
    0
    7
    0
    Base
    60 percent target mRNA inhibition
    18624291
    SM3116
    ACCUGACGUUGUACAAAUUTT
    AAUUUGUACAACGUCAGGUTT
    0
    4-Methylbenzimidazole
    0
    1
    0
    Base
    82 percent target mRNA inhibition
    18624291