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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2,5,7,10,11,12,13,14,15,16 are 9
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2978
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    0
    2,5,7,10,11,12,13,14,15,16
    0
    Sugar
    0
    92 percent target mRNA inhibition
    12923253
    SM2979
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    12923253
    SM2981
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 9,10,13
    Sugar
    Sugar
    64 percent target mRNA inhibition
    12923253
    SM2983
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    Sugar
    Sugar
    44 percent target mRNA inhibition
    12923253
    SM2997
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Bromo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    31 percent target mRNA inhibition
    12923253
    SM2998
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Iodo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    42 percent target mRNA inhibition
    12923253
    SM2999
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    Diaminopurine
    2,5,7,10,11,12,13,14,15,16
    4,5,6,7,8,9,10,13,15,16,18
    Sugar
    Base
    35 percent target mRNA inhibition
    12923253
    SM3005
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 15,19
    Sugar
    Sugar; Phosphate
    45 percent target mRNA inhibition
    12923253
    SM3007
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,9
    Sugar
    Sugar; Phosphate
    64 percent target mRNA inhibition
    12923253