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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-O-Methyl are 502
    Results from 50 - 75
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3135
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    91 percent target mRNA inhibition
    18637735
    SM3136
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    92 percent target mRNA inhibition
    18637735
    SM3138
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    12,15,16,21,22,24
    Sugar
    Sugar
    67 percent target mRNA inhibition
    18637735
    SM3143
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    14 percent target mRNA inhibition
    18637735
    SM3145
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro* 2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    3 percent target mRNA inhibition
    18637735
    SM3150
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    80 percent target mRNA inhibition
    18637735
    SM3152
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    76 percent target mRNA inhibition
    18637735
    SM3153
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    95 percent target mRNA inhibition
    18637735
    SM3154
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    85 percent target mRNA inhibition
    18637735
    SM3156
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    12,15,16,21,22,24
    Sugar
    Sugar
    64 percent target mRNA inhibition
    18637735
    SM3161
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    30 percent target mRNA inhibition
    18637735
    SM3163
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro* 2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    8 percent target mRNA inhibition
    18637735
    SM3168
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3170
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    7,9,11,13,15,17,19,21,23,25
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3171
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    66 percent target mRNA inhibition
    18637735
    SM3172
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    40 percent target mRNA inhibition
    18637735
    SM3174
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    12,15,16,21,22,24
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3179
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3181
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    2-Fluoro* 2-O-Methyl
    1,3,6,7,8,9,12,13,15,16,17,18
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3185
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    31 percent target mRNA inhibition
    18637735
    SM3187
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3191
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3193
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3197
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3199
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    2-O-Methyl
    2,4,6,8,10,12,14,16,18
    9,11,13,15,17,19,21,23,25,26,27
    Sugar
    Sugar
    29 percent target mRNA inhibition
    18637735