SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM3397 |
CCACCACAGCUAGAACUUA UAAGUUCUAGCUGUGGUGG |
2-O-Methyl 2-O-Methyl |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 |
Sugar Sugar |
NA | 16625242 |
SM3398 |
CCACCACAGCUAGAACUUA UAAGUUCUAGCUGUGGUGG |
2-O-Methyl 2-O-Methyl* Cy3 |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 * 19 |
Sugar Sugar |
NA | 16625242 |
SM3399 |
CCAACUUCACCAUCCAGAA UUCUGGAUGGUGAAGUUGG |
2-O-Methyl 2-O-Methyl |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 16625242 |
SM3400 |
GGUGAUAGCCCCGGUGGAU AUCCACCGGGGCUAUCACC |
2-O-Methyl 2-O-Methyl |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 16625242 |
SM3401 |
CCACUUCUGAACUCCAACA UGUUGGAGUUCAGAAGUGG |
2-O-Methyl 2-O-Methyl |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 16625242 |
SM3402 |
CAGAUACUCUAGAACGGAA UUCCGUUCUAGAGUAUCUG |
2-O-Methyl 2-O-Methyl |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 16625242 |
SM3403 |
UCGAAGUAUUCCGCGUACG CGUACGCGGAAUACUUCGA |
2-O-Methyl 2-O-Methyl |
1,3,5,7,9,11,13,15,17,19 2,4,6,8,10,12,14,16,18 |
Sugar Sugar |
NA | 16625242 |
SM3404 |
AUAUCUGGGCAAAUGAUGG CCAUCAUUUGCCCAGAUAU |
2-O-Methyl 2-O-Methyl |
2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19 |
Sugar Sugar |
NA | 16625242 |
SM3409 |
CUGAGUUUAAAAGGCACCCTT TTGACUCAAAUUUUCCGUGGG |
2-O-Methyl 2-O-Methyl* Cholesterol |
20,21 1,2 * 1 |
Sugar Sugar; Phosphate |
IC-50 = 0.05 nM for target mRNA | 16195704 |
SM3443 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7,8 14,15 |
Sugar Sugar |
27 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3445 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7,8 15 |
Sugar Sugar |
56 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3446 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7 15 |
Sugar Sugar |
81 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3447 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7 14 |
Sugar Sugar |
49 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3451 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7,8 14 |
Sugar Sugar |
23 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3452 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
8 14,15 |
Sugar Sugar |
41 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3454 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
8 15 |
Sugar Sugar |
83 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3455 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 0 |
7,8 0 |
Sugar 0 |
59 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3457 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 0 |
8 0 |
Sugar 0 |
85 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3459 |
AGCGCUUAAAGGGCGAGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 0 |
7 0 |
Sugar 0 |
53 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3461 |
AGCGCUUAAAGGGCGGAAGAUU UCUUCUCGCCCUUUAAGCGCUUU |
2-O-Methyl 2-O-Methyl |
7 14 |
Sugar Sugar |
50 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3469 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
14,15,20,21 4,5,7,8,11,13,16,20,21 |
Sugar Sugar |
24 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3470 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
14,15,20,21 7,8 |
Sugar Sugar |
51 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3471 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
1,2,6,9,11,14,15,17,18,20,21 7,8 |
Sugar Sugar |
44 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3472 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
1,2,6,9,11,14,15,17,18,20,21 1,2,4,5,7,8,11,13,16,20,21 |
Sugar Sugar |
7 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |
SM3473 |
AACCCACCACAGCUAGAACUU AAGUUCUAGCUGUGGUGGGUU |
2-O-Methyl 2-O-Methyl |
14,20,21 7 |
Sugar Sugar |
81 percent target mRNA inhibition | US20120088815A1, EP2415869A1 |