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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 20 are 83
Results from 75 - 100

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4554	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	76 percent target mRNA inhibition	22260772
SM4568	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	94 percent target mRNA inhibition	22260772
SM4569	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4583	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	95 percent target mRNA inhibition	22260772
SM4584	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4592	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Sugar; Backbone Sugar	81 percent target mRNA inhibition	22260772
SM4596	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Sugar; Backbone Sugar	89 percent target mRNA inhibition	22260772
SM4803	GGAUCAUCUCAAGUCUUACTT GUAAGACUUGAGAUGAUCCTT	Phosphorothioate Phosphorothioate	20 20	Sugar Sugar	IC-50 = 0.0095 nM for target mRNA	WO2014022739A3



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