Representation of Major Biochemical Pathway categories by the genes in PCMdb


A list of genes in PCMdb that can be classified as "Negative Regulators of Signaling" by UniProt database has been provided below.

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Gene Symbol Gene Name # of Entries
HTR1B5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled1
ADRA1Aadrenoceptor alpha 1A31
ADRA2Aadrenoceptor alpha 2A10
ADAM8adenosine deaminase1
ADMadrenomedullin1
JUBajuba LIM protein1
AKT1v-akt murine thymoma viral oncogene homolog 19
AMBPalpha-1-microglobulin/bikunin precursor20
FAM123BAPC membrane recruitment protein 19
FAM123AAPC membrane recruitment protein 210
ANKRD6ankyrin repeat domain 61
AP2A1adaptor-related protein complex 2, alpha 1 subunit9
AP2A2adaptor-related protein complex 2, alpha 2 subunit1
TEX2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)1
APCadenomatosis polyposis coli 2244
APCDD1Ladenomatous polyposis coli1
APOA1apolipoprotein A-I13
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 720
ADAMTSL2ADAMTS-like 21
ATXN1ataxin 11
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)1
BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)9
BARX1BARX homeobox 110
BCL2L2B-cell CLL/lymphoma 21
BCL6B-cell CLL/lymphoma 61
BMP4bone morphogenetic protein 414
BMP7bone morphogenetic protein 729
IMPBRCA1 associated protein0
CDH23cadherin 2, type 1, N-cadherin (neuronal)1
CASP8caspase 8, apoptosis-related cysteine peptidase13
C19orf29cactin, spliceosome C complex subunit1
CAV2caveolin 21
CBLBCbl proto-oncogene, E3 ubiquitin protein ligase B1
CBLCCbl proto-oncogene, E3 ubiquitin protein ligase C40
CCL5chemokine (C-C motif) ligand 520
CCND1cyclin D114
CD44CD44 molecule (Indian blood group)5
CHST10carbohydrate (chondroitin 4) sulfotransferase 1120
CIDEAcell death-inducing DFFA-like effector a50
CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 11
CMYA5cardiomyopathy associated 51
CYP26B1cytochrome P450, family 26, subfamily B, polypeptide 130
CYP26C1cytochrome P450, family 26, subfamily C, polypeptide 111
CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 11
CRHR2corticotropin releasing hormone receptor 241
CRIPAKcysteine-rich PAK1 inhibitor9
DAB1Dab, reelin signal transducer, homolog 1 (Drosophila)37
DACT3dishevelled-binding antagonist of beta-catenin 31
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked1
DGKZdiacylglycerol kinase, zeta20
DKK1dickkopf WNT signaling pathway inhibitor 16
DKK2dickkopf WNT signaling pathway inhibitor 246
Dkk3dickkopf WNT signaling pathway inhibitor 34
DKK3dickkopf WNT signaling pathway inhibitor 36
DLK1delta-like 1 homolog (Drosophila)103
C1orf187dorsal inhibitory axon guidance protein1
DRD1dopamine receptor D120
DRD2dopamine receptor D231
DRD5dopamine receptor D520
DUSP18dual specificity phosphatase 181
DUSP22dual specificity phosphatase 222
DUSP4dual specificity phosphatase 410
DUSP5dual specificity phosphatase 51
DUSP6dual specificity phosphatase 64
DUSP9dual specificity phosphatase 91
EGR1early growth response 19
EPHA2EPH receptor A21
ESR1estrogen receptor 1109
FBP1fructose-1,6-bisphosphatase 11
FBN2fibrillin 264
FGFR3fibroblast growth factor receptor 31
FZD10frizzled family receptor 131
GAS1growth arrest-specific 113
GAS6growth arrest-specific 610
GATA2GATA binding protein 231
GATA3GATA binding protein 311
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 11
GDNFglial cell derived neurotrophic factor50
SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 220
GLRA1glycine receptor, alpha 120
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 29
GPC1glypican 11
GREM1gremlin 1, DAN family BMP antagonist30
GRIK1glutamate receptor, ionotropic, kainate 130
GRIK3glutamate receptor, ionotropic, kainate 351
GSC2goosecoid homeobox10
GSTP1glutathione S-transferase pi 163
GSTpglutathione S-transferase pi 130
HDAC1histone deacetylase 113
HEY1hairy/enhancer-of-split related with YRPW motif 19
HEYLhairy/enhancer-of-split related with YRPW motif-like20
HHEXhematopoietically expressed homeobox1
HHIPL1hedgehog interacting protein1
HIC1hypermethylated in cancer 126
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor9
ONECUT1one cut homeobox 110
HYAL2hyaluronoglucosaminidase 21
IGFBP3insulin-like growth factor binding protein 3110
IGFBP5insulin-like growth factor binding protein 533
IGF1Rinsulin-like growth factor 1 receptor10
NFKBIDnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta9
IL1Binterleukin 1, beta20
IL1RNinterleukin 1 receptor antagonist33
IL8interleukin 813
IRF4interferon regulatory factor 430
IRS1insulin receptor substrate 11
ISL1ISL LIM homeobox 11
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta21
KDM1lysine (K)-specific demethylase 1A1
KIF26Akinesin family member 26A10
KIF7kinesin family member 71
PRKCAprotein kinase C, alpha10
PRKCBprotein kinase C, beta10
PRKCB1protein kinase C, beta21
PRKCZprotein kinase C, zeta1
LECT1leukocyte cell derived chemotaxin 120
LEMD2LEM domain containing 29
LIFleukemia inhibitory factor13
ZFYVE28zinc finger, FYVE domain containing 281
MAGmelanoma antigen family A, 1 (directs expression of antigen MZ2-E)1
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)1
MDFICMyoD family inhibitor1
MDM2MDM2 oncogene, E3 ubiquitin protein ligase9
MEN1multiple endocrine neoplasia I24
MGRN1mahogunin ring finger 1, E3 ubiquitin protein ligase1
MMRN2multimerin 29
NBL1neuroblastoma 1, DAN family BMP antagonist13
SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 29
NEUROD1neuronal differentiation 149
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase1
NKD2naked cuticle homolog 2 (Drosophila)10
NKX2-1NK2 homeobox 110
TITF1NK2 homeobox 120
NKX2-5NK2 homeobox 530
CARD15nucleotide-binding oligomerization domain containing 213
NODALnodal growth differentiation factor10
NOTCH1notch 11
NPY2Rneuropeptide Y receptor Y510
NR0B1nuclear receptor subfamily 0, group B, member 11
NR1D1nuclear receptor subfamily 1, group D, member 11
ONECUT2one cut homeobox 210
OPRM1opioid receptor, mu 140
TP53tumor protein p531
TP73tumor protein p73100
p73tumor protein p7388
P73tumor protein p7356
PALM2paralemmin1
PDPK13-phosphoinositide dependent protein kinase-120
PEG10paternally expressed 1021
COX2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)11
PPARGC1Bperoxisome proliferator-activated receptor gamma1
PPM1Aprotein phosphatase, Mg2+/Mn2+ dependent, 1A1
PRAMEF2PRAME family member 220
PRDM16PR domain containing 1619
PTCH1patched 11
PTCH2patched 213
PTENphosphatase and tensin homolog9
PTPN6protein tyrosine phosphatase, non-receptor type 613
PTPRJprotein tyrosine phosphatase, receptor type, J20
PTPROprotein tyrosine phosphatase, receptor type, O40
PXDNperoxidasin homolog (Drosophila)50
RASA3RAS p21 protein activator 310
RGS12regulator of G-protein signaling 129
RGS17regulator of G-protein signaling 1754
RGS20regulator of G-protein signaling 2026
RGSL1regulator of G-protein signaling like 120
DLC1deleted in liver cancer 113
UBA52ubiquitin A-52 residue ribosomal protein fusion product 11
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)10
ROR2receptor tyrosine kinase-like orphan receptor 230
RPH3ALrabphilin 3A-like (without C2 domains)10
RUNX2runt-related transcription factor 21
SALL1sal-like 1 (Drosophila)31
SALL3sal-like 3 (Drosophila)51
SLC6A19solute carrier family 6 (neurotransmitter transporter, GABA), member 11
SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 420
SFRP1secreted frizzled-related protein 1105
SARP2secreted frizzled-related protein 1235
SFRP2secreted frizzled-related protein 271
FRZBfrizzled-related protein63
SFRP4secreted frizzled-related protein 43
SFRP5secreted frizzled-related protein 52
SH3GL2SH3-domain GRB2-like 251
SHHsonic hedgehog10
SIGIRRsingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain1
MAPKAP1mitogen-activated protein kinase associated protein 11
SIX3SIX homeobox 39
SKIv-ski sarcoma viral oncogene homolog (avian)1
LBXCOR1SKI family transcriptional corepressor 110
SLIT2slit homolog 2 (Drosophila)64
SLIT3slit homolog 3 (Drosophila)30
SMURF1SMAD specific E3 ubiquitin protein ligase 11
SOCS1suppressor of cytokine signaling 1233
SOCS2suppressor of cytokine signaling 2130
SOSTDC1sclerostin domain containing 120
SOX1SRY (sex determining region Y)-box 1043
SOX15SRY (sex determining region Y)-box 1751
SOX2SRY (sex determining region Y)-box 21
SPG20spastic paraplegia 20 (Troyer syndrome)40
SPRED2sprouty-related, EVH1 domain containing 21
SPRED3sprouty-related, EVH1 domain containing 310
SRCIN1v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1
STK38serine/threonine kinase 3820
STMN3stathmin-like 31
SNCAIPsynuclein, alpha (non A4 component of amyloid precursor)41
TBX1T-box 1813
TBX18T-box 2010
TCF15transcription factor 2110
TNRC18tenascin R10
TCF7L1transcription factor 7-like 2 (T-cell specific, HMG-box)1
TGFAtransforming growth factor, beta 11
TGFB2transforming growth factor, beta receptor II (70/80kDa)13
TGFBR2TGFB-induced factor homeobox 11
THPOThy-1 cell surface antigen20
TJP2transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)30
TLL2toll-like receptor 99
NGFRnerve growth factor receptor9
TRIM33tripartite motif containing 339
TRIM67tripartite motif containing 6710
THthrombospondin 110
TWIST1twist basic helix-loop-helix transcription factor 1144
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)121
AVPR1Aarginine vasopressin receptor 1A10
VWC2von Willebrand factor C domain containing 210
WNK2WNK lysine deficient protein kinase 220
WNT10Bwingless-type MMTV integration site family, member 110
WNT3wingless-type MMTV integration site family, member 3A10
WNT5Awingless-type MMTV integration site family, member 5A10
WWOXWW domain containing oxidoreductase26
WWTR1WW domain containing transcription regulator 11
XDHxanthine dehydrogenase40
ZFYVE9zinc finger, FYVE domain containing 99
ZMYND11zinc finger, MYND-type containing 111
ZNF536zinc finger protein 53610
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