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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2 are 29
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2499
    TTCGUUAGCAGAAACAAAAGGAG
    TTCUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2504
    TTUGGAAUGAACCACUGGAAUUU
    TTAAAUUCCAGUGGUUCAUUCCA
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2534
    UCUUGAUGUACUCCCCUCG
    CGAGGGGAGUACAUCAAGA
    2-Deoxythymidine
    0
    1,2
    0
    Sugar
    0
    NA
    12771196
    SM3292
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Altritol nucleic acid
    0
    1,2
    0
    Sugar
    0
    36 percent target mRNA inhibition
    17264131
    SM4232
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    0
    1,2
    0
    Sugar
    0
    93 percent target mRNA inhibition
    25233814
    SM4236
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    22,23
    Sugar
    Sugar
    89 percent target mRNA inhibition
    25233814
    SM4237
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    1,2
    Sugar
    Sugar
    78 percent target mRNA inhibition
    25233814
    SM4244
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    1,2,22,23
    Sugar
    Sugar
    76 percent target mRNA inhibition
    25233814
    SM4251
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    0
    1,2
    0
    Sugar
    0
    96 percent target mRNA inhibition
    25233814
    SM4255
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    22,23
    Sugar
    Sugar
    87 percent target mRNA inhibition
    25233814
    SM4256
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    1,2
    Sugar
    Sugar
    90 percent target mRNA inhibition
    25233814
    SM4263
    AACCUUACCCACCUCAUGUAUCU
    AGAUACAUGAGGUGGGUAAGGUU
    Serinol nucleic acid
    Serinol nucleic acid
    1,2
    1,2,22,23
    Sugar
    Sugar
    90 percent target mRNA inhibition
    25233814
    SM4686
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    2 * 1
    Sugar
    Sugar
    70 percent target mRNA inhibition
    EP2548962A1
    SM4687
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    0
    Sugar
    Sugar
    72 percent target mRNA inhibition
    EP2548962A1
    SM4695
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    Locked nucleic acid
    1,2
    2 * 1
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4696
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    Locked nucleic acid
    0
    1,2
    0
    Sugar
    0
    0 percent target mRNA inhibition
    EP2548962A1
    SM4702
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    2-O-Methyl
    2-O-Methyl* Phosphate
    1,2
    2 * 1
    Sugar
    Sugar
    68 percent target mRNA inhibition
    EP2548962A1
    SM4708
    NNNNNNNNNNNNNNNNNNNNNN
    NNNNNNNNNNNNNNNNNNNNNN
    2-O-Methyl
    2-O-Methyl* Phosphate
    1,2
    2 * 1
    Sugar
    Sugar
    0 percent target mRNA inhibition
    EP2548962A1
    SM4878
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2
    0
    Sugar
    0
    95.5 percent target mRNA inhibition
    17150641
    SM4883
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2
    18,19
    Sugar
    Sugar
    91.3 percent target mRNA inhibition
    17150641
    SM4886
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2
    0
    Sugar
    0
    69.5 percent target mRNA inhibition
    17150641
    SM4891
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2
    18,19
    Sugar
    Sugar
    72.4 percent target mRNA inhibition
    17150641
    SM4899
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2
    0
    Sugar
    0
    95.5 percent target mRNA inhibition
    17924376
    SM4918
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2
    18,19
    Sugar
    Sugar
    91.3 percent target mRNA inhibition
    17924376
    SM4928
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2
    1,2,18,19
    Sugar
    Sugar
    90.4 percent target mRNA inhibition
    17924376