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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 12923253 are 29
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2977
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro
    0
    1,2,3,11,12,14,16,17,19
    0
    Sugar
    83 percent target mRNA inhibition
    12923253
    SM2978
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    0
    2,5,7,10,11,12,13,14,15,16
    0
    Sugar
    0
    92 percent target mRNA inhibition
    12923253
    SM2979
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    12923253
    SM2980
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* 2-Deoxy
    0
    1,2,3,11,12,14,16,17,19 * 9,10,13
    0
    Sugar
    85 percent target mRNA inhibition
    12923253
    SM2981
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 9,10,13
    Sugar
    Sugar
    64 percent target mRNA inhibition
    12923253
    SM2982
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* 2-Deoxy
    0
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    0
    Sugar
    42 percent target mRNA inhibition
    12923253
    SM2983
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    Sugar
    Sugar
    44 percent target mRNA inhibition
    12923253
    SM2984
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2985
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    38 percent target mRNA inhibition
    12923253
    SM2986
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    2-Deoxy
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2987
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    16 percent target mRNA inhibition
    12923253
    SM2988
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    25 percent target mRNA inhibition
    12923253
    SM2989
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-O-Methyl
    2-O-Methyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM2990
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Phosphate
    42 percent target mRNA inhibition
    12923253
    SM2991
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Phosphate
    0
    62 percent target mRNA inhibition
    12923253
    SM2992
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Phosphate
    Phosphate
    47 percent target mRNA inhibition
    12923253
    SM2993
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    2-Fluoro* Phosphorothioate
    0
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    0
    Sugar; Phosphate
    22 percent target mRNA inhibition
    12923253
    SM2994
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    5-Bromo-Uridine
    0
    2,3,11,14,17
    0
    Base
    70 percent target mRNA inhibition
    12923253
    SM2995
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    5-Iodo-Uridine
    0
    2,3,11,14,17
    0
    Base
    59 percent target mRNA inhibition
    12923253
    SM2996
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    Diaminopurine
    0
    4,5,6,7,8,9,10,13,15,16,18
    0
    Base
    51 percent target mRNA inhibition
    12923253
    SM2997
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Bromo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    31 percent target mRNA inhibition
    12923253
    SM2998
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Iodo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    42 percent target mRNA inhibition
    12923253
    SM2999
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    Diaminopurine
    2,5,7,10,11,12,13,14,15,16
    4,5,6,7,8,9,10,13,15,16,18
    Sugar
    Base
    35 percent target mRNA inhibition
    12923253
    SM3000
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    N-3 Methyluridine
    0
    2,3,11,14,17
    0
    Base
    0 percent target mRNA inhibition
    12923253
    SM3001
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    0
    N-3 Methyluridine
    0
    11
    0
    Base
    0 percent target mRNA inhibition
    12923253