SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM4746 |
CAUUGGUGAAGGAUCCAGGA UCCUGGAUCCUUCACCAAUG |
0 2-O-Methylribose |
0 6,12,15,18,19,20 |
0 Sugar |
IC-50 = 0.022859 nM for target mRNA | US 8394947 B2 |
SM4747 |
CAUUGGUGAAGGAUCCAGGA CCUGGAUCCUUCACCAAUG |
0 2-O-Methylribose |
0 5,6,9,10,17,18,19 |
0 Sugar |
IC-50 = 0.01205 nM for target mRNA | US 8394947 B2 |
SM4748 |
AGAAGACACCUUCUGAGUAU AUACUCAGAAGGUGUCUUCU |
0 2-O-Methylribose |
0 6,7,10,11,18,19,20 |
0 Sugar |
IC-50 = 0.075517 nM for target mRNA | US 8394947 B2 |
SM4749 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
0 2-O-Methylribose |
0 5,8,11,14,17,18,19 |
0 Sugar |
IC-50 = 0.17024 nM for target mRNA | US 8394947 B2 |
SM4750 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
0 2-O-Methylribose |
0 6,7,10,11,17,18,19 |
0 Sugar |
IC-50 = 0.055386 nM for target mRNA | US 8394947 B2 |
SM4751 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
4-Thioribose* Phosphorothioate 2-O-Methylribose |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 6,7,10,11,17,18,19 |
Sugar; Phosphate-linkage Sugar |
IC-50 = 0.11222 nM for target mRNA | US 8394947 B2 |
SM4752 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
4-Thioribose* Phosphorothioate 2-O-Methylribose |
1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 5,8,11,14,17,18,19 |
Sugar; Phosphate-linkage Sugar |
IC-50 = 0.96445 nM for target mRNA | US 8394947 B2 |
SM4753 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-Methylribose 2-O-Methylribose |
2,4,6,8,10,12,14,16,18 5,8,11,14,17,18,20 |
Sugar Sugar |
IC-50 = 0.21527 nM for target mRNA | US 8394947 B2 |
SM4754 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-Methylribose 2-O-Methylribose |
2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 5,8,11,14,17,18,21 |
Sugar Sugar |
IC-50 = 0.12453 nM for target mRNA | US 8394947 B2 |
SM4755 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-Methylribose 2-O-Methylribose |
2,4,6,8,10,12,14,16,18 6,7,10,11,17,18,19 |
Sugar Sugar |
IC-50 = 0.045167 nM for target mRNA | US 8394947 B2 |
SM4756 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-methoxyethylribose 2-O-Methylribose |
2,4,6,8,10,12,14,16,18 5,8,11,14,17,18,19 |
Sugar Sugar |
IC-50 = 0.47593 nM for target mRNA | US 8394947 B2 |
SM4757 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-methoxyethylribose 2-O-Methylribose |
2,4,6,8,10,12,14,16,19 6,7,10,11,17,18,19 |
Sugar Sugar |
IC-50 = 0.11759 nM for target mRNA | US 8394947 B2 |
SM4758 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
2-O-Methlyribose 2-O-Methylribose |
2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 5,8,11,14,17,18,19 |
Sugar Sugar |
IC-50 = 0.075608 nM for target mRNA | US 8394947 B2 |
SM4759 |
AGAAGACACCUUCUGAGUAU AUACUCAGAAGGUGUCUUCU |
2-O-Methylribose 2-O-Methylribose |
2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,20 6,7,10,11,18,19,20 |
Sugar Sugar |
IC-50 = 0.025677 nM for target mRNA | US 8394947 B2 |
SM4778 |
GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC |
0 2-O-Methylribose |
0 15,16,17,18,19 |
0 Phosphate-linkage |
IC-50 = 0.031541 nM for target mRNA | US 8394947 B2 |