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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 600 - 625
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4794
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,10,19
    0
    Sugar
    80 percent target mRNA inhibition
    US 8394947 B2
    SM4797
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,10,19
    0
    Sugar
    70 percent target mRNA inhibition
    US 8394947 B2
    SM4798
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    60 percent target mRNA inhibition
    US 8394947 B2
    SM4800
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    61 percent target mRNA inhibition
    US 8394947 B2
    SM4801
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    25 percent target mRNA inhibition
    US 8394947 B2
    SM4802
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    51 percent target mRNA inhibition
    US 8394947 B2
    SM4829
    UGAAUCAGAAGAUGAAGUCAA
    GACUUCAUCUUCUGAUUCAAG
    0
    unlocked nucleic acid
    0
    1
    0
    Sugar
    94 percent target mRNA inhibition
    23820891
    SM4833
    UGAAUCAGAAGAUGAAGUCAA
    GACUUCAUCUUCUGAUUCAAG
    0
    unlocked nucleic acid
    0
    1
    0
    Sugar
    92 percent target mRNA inhibition
    23820891
    SM4861
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,7,9,10,16
    0
    Sugar
    79.5 percent target mRNA inhibition (IC-50 = 1.65 nM)
    15919084
    SM4862
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    2,11,12,14,18
    0
    Sugar
    68.5 percent target mRNA inhibition (IC-50 = 2.09 nM)
    15919084
    SM4863
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,7,9,10,11,12,14,16,18
    0
    Sugar
    27.5 percent target mRNA inhibition
    15919084
    SM4864
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    16.6 percent target mRNA inhibition
    15919084
    SM4869
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6
    0
    Sugar
    70.9 percent target mRNA inhibition (IC-50 = 2.62 nM)
    15919084
    SM4870
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    14,15,16,17,18,19
    0
    Sugar
    72.2 percent target mRNA inhibition (IC-50 = 1.98 nM)
    15919084
    SM4871
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    7,8,9,10,11,12,13
    0
    Sugar
    36.5 percent target mRNA inhibition
    15919084
    SM4872
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    22.8 percent target mRNA inhibition
    15919084
    SM4875
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    2-O-Methyl
    0
    1,2,3,4,5,6
    0
    Sugar
    10.3 percent target mRNA inhibition
    15919084
    SM4876
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    2-O-Methyl
    0
    14,15,16,17,18,19
    0
    Sugar
    30.8 percent target mRNA inhibition
    15919084
    SM4881
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    18,19
    0
    Sugar
    90.2 percent target mRNA inhibition
    17150641
    SM4882
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    16,17,18,19
    0
    Sugar
    85.6 percent target mRNA inhibition
    17150641
    SM4889
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    0
    4-Thioribose
    0
    18,19
    0
    Sugar
    57.2 percent target mRNA inhibition
    17150641
    SM4890
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    0
    4-Thioribose
    0
    16,17,18,19
    0
    Sugar
    52.7 percent target mRNA inhibition
    17150641
    SM4903
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4,5,6
    0
    Sugar
    70.9 percent target mRNA inhibition
    17924376
    SM4904
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    76.7 percent target mRNA inhibition
    17924376
    SM4905
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    0
    4-Thioribose
    0
    1,2
    0
    Sugar
    95 percent target mRNA inhibition
    17924376