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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Fluoro are 24
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2488
    CAGCAAACCACGAUCAAUATT
    UAUUGAUCGUGGUUUGCUGTT
    2-Fluoro
    2-Fluoro
    1,4,8,9,11,14,15,18
    1,3,4,7,8,10,13,14,15,17,18
    Sugar
    Sugar
    71 percent target mRNA inhibition
    22889374
    SM2491
    CAGAGCAAUUGUUUACCUATT
    UAGGUAAACAAUUGCUCUGTT
    2-Fluoro
    2-Fluoro
    1,6,9,10,12,13,14,16,17,18
    1,5,9,12,13,15,16,17
    Sugar
    Sugar
    72 percent target mRNA inhibition
    22889374
    SM2978
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    0
    2,5,7,10,11,12,13,14,15,16
    0
    Sugar
    0
    92 percent target mRNA inhibition
    12923253
    SM2979
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19
    Sugar
    Sugar
    83 percent target mRNA inhibition
    12923253
    SM2981
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 9,10,13
    Sugar
    Sugar
    64 percent target mRNA inhibition
    12923253
    SM2983
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,8,9,10,13,15,18
    Sugar
    Sugar
    44 percent target mRNA inhibition
    12923253
    SM2997
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Bromo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    31 percent target mRNA inhibition
    12923253
    SM2998
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    5-Iodo-Uridine
    2,5,7,10,11,12,13,14,15,16
    2,3,11,14,17
    Sugar
    Base
    42 percent target mRNA inhibition
    12923253
    SM2999
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    Diaminopurine
    2,5,7,10,11,12,13,14,15,16
    4,5,6,7,8,9,10,13,15,16,18
    Sugar
    Base
    35 percent target mRNA inhibition
    12923253
    SM3005
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 15,19
    Sugar
    Sugar; Phosphate
    45 percent target mRNA inhibition
    12923253
    SM3007
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    2-Fluoro* 2-Deoxy
    2,5,7,10,11,12,13,14,15,16
    1,2,3,11,12,14,16,17,19 * 4,5,6,7,9
    Sugar
    Sugar; Phosphate
    64 percent target mRNA inhibition
    12923253
    SM3139
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    88 percent target mRNA inhibition
    18637735
    SM3141
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    85 percent target mRNA inhibition
    18637735
    SM3142
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    81 percent target mRNA inhibition
    18637735
    SM3146
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    65 percent target mRNA inhibition
    18637735
    SM3157
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18637735
    SM3159
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    78 percent target mRNA inhibition
    18637735
    SM3160
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    78 percent target mRNA inhibition
    18637735
    SM3164
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    47 percent target mRNA inhibition
    18637735
    SM3175
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    55 percent target mRNA inhibition
    18637735
    SM3177
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3178
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-O-Methyl
    2,4,5,10,11,14,19,20
    12,15,16,21,22,24
    Sugar
    Sugar
    0 percent target mRNA inhibition
    18637735
    SM3182
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    2-Fluoro* 2-O-Methyl
    2,4,5,10,11,14,19,20
    8,9,10,11,13,14,17,18,19,20,23,25,26 * 12,15,16,21,22,24
    Sugar
    Sugar
    3 percent target mRNA inhibition
    18637735
    SM3395
    CCACCACAGCUAGAACUUA
    GGUGGUGUCGAUCUUGAAU
    2-Fluoro
    2-Fluoro
    2,4,6,8,10,12,14,16,18
    1,3,5,7,9,11,13,15,17,19
    Sugar
    Sugar
    NA
    16625242