Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 325 - 350
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2098
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    75.4 percent target mRNA inhibition
    19282453
    SM2102
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    5,20,21
    20,21
    Sugar
    Sugar
    66.3 percent target mRNA inhibition
    19282453
    SM2103
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,5,7,9,20,21
    20,21
    Sugar
    Sugar
    51.9 percent target mRNA inhibition
    19282453
    SM2104
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    74.6 percent target mRNA inhibition
    19282453
    SM2115
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,8,13,15,20,21
    20,21
    Sugar
    Sugar
    84.1 percent target mRNA inhibition
    19282453
    SM2116
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    84.6 percent target mRNA inhibition
    19282453
    SM2140
    GACGUAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    13.4 percent target mRNA inhibition
    19282453
    SM2143
    GACGUAAACG + GCCACAAGUTC
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    17.8 percent target mRNA inhibition
    19282453
    SM2147
    GACGTAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    5,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    10.6 percent target mRNA inhibition
    19282453
    SM2148
    GACGTAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    3,5,7,9,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    7.6 percent target mRNA inhibition
    19282453
    SM2149
    GACGUAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM2160
    GACGUAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    3,8,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    1.5 percent target mRNA inhibition
    19282453
    SM2161
    GACGUAAACGGCCACAAGUTC
    ACTUGTGGCCGUUTACGTCGC
    Locked nucleic acid
    Locked nucleic acid
    20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    3 percent target mRNA inhibition
    19282453
    SM2185
    GACGUAAACG; GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    NA
    19401674
    SM2186
    GACGUAAACGGCCACAAGUTC
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    NA
    19401674
    SM2189
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    20,21
    Sugar
    Sugar
    NA
    19401674
    SM2194
    GCAGCACGACUUCUUCAAGUU
    CUUGAAGAAGUCGUGCUGCUU
    Locked nucleic acid
    0
    1
    0
    Sugar
    0
    73.23 percent target mRNA inhibition
    18575806
    SM2195
    GCAGCACGACUUCUUCAAGUU
    CUUGAAGAAGUCGUGCUGCUU
    Locked nucleic acid
    2-O-Methyl
    1
    2
    Sugar
    Sugar
    68.59 percent target mRNA inhibition
    18575806
    SM2196
    GCAGCACGACUUCUUCAAGUU
    CUUGAAGAAGUCGUGCUGCUU
    Locked nucleic acid
    2-Fluoro
    1
    2
    Sugar
    Sugar
    69.33 percent target mRNA inhibition
    18575806
    SM2201
    UAGUUCUGUGGGGCUGUUUUU
    AAACAGCCCCACAGAACUAUU
    Locked nucleic acid
    2-Fluoro
    1
    2
    Sugar
    Sugar
    NA
    18575806
    SM2483
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Locked nucleic acid
    0
    1
    0
    Sugar
    0
    86 percent target mRNA inhibition
    22982308
    SM2484
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    83 percent target mRNA inhibition
    22982308
    SM2485
    GTCATCACACUGAATACCAAUTT
    AUUGGUAUUCAGUGUGAUGACTT
    Locked nucleic acid
    2,4-Locked nucleic acid
    1,2,5,15,18,22,23
    22,23
    Sugar
    Sugar
    High target target mRNA inhibition efficacy
    22974833
    SM2583
    GCUGACCCUGAAGUUCAUCTT
    GAUGAACUUCAGGGUCAGCTT
    Locked nucleic acid
    Locked nucleic acid
    1,20,21
    20,21
    Sugar
    Sugar
    61 percent target mRNA inhibition
    17363479
    SM2584
    GCTGACCCUGAAGTTCAUCTT
    GAUGAACUUCAGGGUCAGCTT
    Locked nucleic acid
    Locked nucleic acid
    1,2,3,7,10,14,15,20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    17363479