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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Phosphorothioate are 23
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2187
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Phosphorothioate
    Locked nucleic acid
    1,2,3,4,5,16,17,18,19,20
    20,21
    Sugar
    Sugar
    NA
    19401674
    SM2240
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,3,4
    2,3,4
    Phosphate
    Phosphate
    75 percent target mRNA inhibition
    16598842
    SM2241
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    17,18,19
    17,18,19
    Phosphate
    Phosphate
    79 percent target mRNA inhibition
    16598842
    SM2242
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,3,4,17,18,19
    2,3,4,17,18,19
    Phosphate
    Phosphate
    78 percent target mRNA inhibition
    16598842
    SM2252
    AAGGAGAUCAACAUUUUCATT
    UGAAAAUGUUGAUCUCCUUTT
    Phosphorothioate
    Phosphorothioate
    2,4,6,8,10,12,14,16,18
    2,4,6,8,10,12,14,16,18
    Phosphate
    Phosphate
    74 percent target mRNA inhibition
    16598842
    SM2941
    AAGCUGACCCUGAAGUUCAUCUGCACC
    GGUGCAGAUGAACUUCAGGGUCAGCUU
    Phosphorothioate
    Phosphorothioate
    2,27
    2,27
    Phosphate
    Phosphate
    95 percent target mRNA inhibition
    21739319
    SM2942
    AAGCUGACCCUGAAGUUCAUCUGCACC
    GGUGCAGAUGAACUUCAGGGUCAGCUU
    Phosphorothioate
    Phosphorothioate
    2,3,4,25,26,27
    2,3,4,25,26,27
    Phosphate
    Phosphate
    93 percent target mRNA inhibition
    21739319
    SM2947
    AAGCUGACCCUGAAGUUCAUCUGCACC
    GGUGCAGAUGAACUUCAGGGUCAGCUU
    Phosphorothioate
    Phosphorothioate
    2,27
    2,27
    Phosphate
    Phosphate
    93 percent target mRNA inhibition
    21739319
    SM2948
    AAGCUGACCCUGAAGUUCAUCUGCACC
    GGUGCAGAUGAACUUCAGGGUCAGCUU
    Phosphorothioate
    Phosphorothioate
    2,3,4,25,26,27
    2,3,4,25,26,27
    Phosphate
    Phosphate
    93 percent target mRNA inhibition
    21739319
    SM2991
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Phosphate
    0
    62 percent target mRNA inhibition
    12923253
    SM2992
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Phosphate
    Phosphate
    47 percent target mRNA inhibition
    12923253
    SM3017
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Phosphorothioate
    0
    4,6,7,14,15,19
    0
    Phosphate
    0
    85 percent target mRNA inhibition
    15545637
    SM3019
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Phosphorothioate
    0
    2,3,8,9,12,17,18,20,21
    0
    Phosphate
    0
    45 percent target mRNA inhibition
    15545637
    SM3326
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    Phosphorothioate
    0
    1,2,39,40
    0
    Phosphate
    0
    93 percent target mRNA inhibition
    19948766
    SM3327
    UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA
    0
    Phosphorothioate
    0
    1,2,39,40
    0
    Phosphate
    0
    87 percent target mRNA inhibition
    19948766
    SM3351
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Phosphorothioate
    Phosphorothioate
    1,2,20,21
    1,2,20,21
    Phosphate
    Phosphate
    NA
    12834349
    SM3352
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,18,19,20,21
    1,2,3,4,18,19,20,21
    Phosphate
    Phosphate
    NA
    12834349
    SM3353
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,15,16,17,18,19,20,21
    1,2,3,4,5,6,15,16,17,18,19,20,21
    Phosphate
    Phosphate
    NA
    12834349
    SM3354
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,7,8,14,15,16,17,18,19,20,21
    1,2,3,4,5,6,7,8,14,15,16,17,18,19,20,21
    Phosphate
    Phosphate
    NA
    12834349
    SM3355
    AGACGAGCUGAGCGAGAAGTT
    TTUCUGCUCGACUCGCUCUUC
    Phosphorothioate
    Phosphorothioate
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,14,15,16,17,18,19,20,21
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    Phosphate
    Phosphate
    NA
    12834349
    SM3370
    GAACUGUGUGUGAGAGGUCCU
    AGGACCUCUCACACACAGUUCGC
    Phosphorothioate
    Phosphorothioate* 2-O-Methyl
    21
    21,22 * 21,22
    Phosphate
    Phosphate; Sugar
    80 percent target mRNA inhibition
    21663557
    SM3371
    AGCUAGUCGUAGUGGAUGCGU
    ACGCAUCCACUACGACUAGCUCGC
    Phosphorothioate
    Phosphorothioate* 2-O-Methyl
    21
    22,23 * 22,23
    Phosphate
    Phosphate; Sugar
    NA
    21663557
    SM4803
    GGAUCAUCUCAAGUCUUACTT
    GUAAGACUUGAGAUGAUCCTT
    Phosphorothioate
    Phosphorothioate
    20
    20
    Sugar
    Sugar
    IC-50 = 0.0095 nM for target mRNA
    WO2014022739A3