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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Triazole-linked nucleic acid are 21
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4382	CUUACGCUGAGUACUUCGAUU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Phosphate Sugar	93 percent target mRNA inhibition	25699137
SM4397	CUUACGCUGAGUACUUCGAUU UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Phosphate Sugar	95 percent target mRNA inhibition	25699137
SM4404	GCCUUCUUUGAGUUCGGUGUU CACCGAACUCAAAGAAGGCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Phosphate Sugar	71 percent target mRNA inhibition	25699137
SM4411	GCCUUCUUUGAGUUCGGUGUU CACCGAACUCAAAGAAGGCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Phosphate Sugar	87 percent target mRNA inhibition	25699137
SM4553	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	91 percent target mRNA inhibition	22260772
SM4554	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	76 percent target mRNA inhibition	22260772
SM4555	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	86 percent target mRNA inhibition	22260772
SM4556	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	43 percent target mRNA inhibition	22260772
SM4557	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	49 percent target mRNA inhibition	22260772
SM4568	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	94 percent target mRNA inhibition	22260772
SM4569	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4570	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	98 percent target mRNA inhibition	22260772
SM4571	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	81 percent target mRNA inhibition	22260772
SM4572	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	74 percent target mRNA inhibition	22260772
SM4583	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Backbone Sugar	95 percent target mRNA inhibition	22260772
SM4584	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	20 20	Backbone Backbone	96 percent target mRNA inhibition	22260772
SM4585	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	15,20 20,21	Backbone Sugar	97 percent target mRNA inhibition	22260772
SM4586	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid Triazole-linked nucleic acid	15,20 20	Backbone Backbone	85 percent target mRNA inhibition	22260772
SM4587	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	Triazole-linked nucleic acid 2-Deoxythymidine	2,15,20 20,21	Backbone Sugar	77 percent target mRNA inhibition	22260772
SM4592	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Sugar; Backbone Sugar	81 percent target mRNA inhibition	22260772
SM4596	GGUCAUCCAUGACAACUUUTT AAAGUUGUCAUGGAUGACCTT	Triazole-linked nucleic acid 2-Deoxythymidine	20 20,21	Sugar; Backbone Sugar	89 percent target mRNA inhibition	22260772