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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 2-Deoxythymidine are 67
Results from 25 - 50

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4224	UCGGGAAAUUUCUCUAUUATT UAAUAGAGAAAUUUCCCGATT	2-Deoxythymidine L-isonucleoside adenosine* 2-Deoxythymidine	20,21 2 * 20,21	Sugar Sugar ; Sugar	74 percent target mRNA inhibition	22895883
SM4225	UCGGGAAAUUUCUCUAUUATT UAAUAGAGAAAUUUCCCGATT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	80 percent target mRNA inhibition	22895883
SM4228	UCGGGAAAUUUCUCUAUUATT UAAUAGAGAAAUUUCCCGATT	2-Deoxythymidine L-isonucleoside thymidine* 2-Deoxythymidine	20,21 4 * 20,21	Sugar Sugar ; Sugar	70 percent target mRNA inhibition	22895883
SM4229	UCGGGAAAUUUCUCUAUUATT UAAUAGAGAAAUUUCCCGATT	2-Deoxythymidine L-isonucleoside adenosine* 2-Deoxythymidine	20,21 19 * 20,21	Sugar Sugar ; Sugar	90 percent target mRNA inhibition	22895883
SM4230	UCGGGAAAUUUCUCUAUUATT UAAUAGAGAAAUUUCCCGATT	2-Deoxythymidine L-isonucleoside adenosine* 2-Deoxythymidine	20,21 2 * 20,21	Sugar Sugar ; Sugar	89 percent target mRNA inhibition	22895883
SM4371	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	69 percent target mRNA inhibition	25699137
SM4376	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	92 percent target mRNA inhibition	25699137
SM4386	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	89 percent target mRNA inhibition	25699137
SM4391	CUUACGCUCUGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	94 percent target mRNA inhibition	25699137
SM4401	GUGAAGUCAACAUGCCUGCTT GCAGGCAUGUUGACUUCACTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	50 percent target mRNA inhibition	25699137
SM4408	GUGAAGUCAACAUGCCUGCTT GCAGGCAUGUUGACUUCACTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	70 percent target mRNA inhibition	25699137
SM4415	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	30 percent target mRNA inhibition	25699137
SM4419	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	33 percent target mRNA inhibition	25699137
SM4423	CUUACGCUGAGUACUUCGATT UCGAAGUACUCAGCGUAAGTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	75 percent target mRNA inhibition	25699137
SM4484	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	62 percent target mRNA inhibition	12408823
SM4486	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	8 percent target mRNA inhibition	12408823
SM4489	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine* Puromycin	20,21 20,21 * 21	Sugar Sugar	67 percent target mRNA inhibition	12408823
SM4491	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine* Biotin	1 * 20,21 20,21 * 21	Phosphate; Sugar Sugar	61 percent target mRNA inhibition	12408823
SM4492	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	92 percent target mRNA inhibition	12408823
SM4494	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	8 percent target mRNA inhibition	12408823
SM4497	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine* Puromycin	20,21 20,21 * 21	Sugar Sugar	76 percent target mRNA inhibition	12408823
SM4499	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine* Biotin	1 * 20,21 20,21 * 21	Phosphate; Sugar Sugar	95 percent target mRNA inhibition	12408823
SM4500	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine	20,21 20,21	Sugar Sugar	78 percent target mRNA inhibition	12408823
SM4502	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	17 percent target mRNA inhibition	12408823
SM4505	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 2-Deoxythymidine* Puromycin	20,21 20,21 * 21	Sugar Sugar	62 percent target mRNA inhibition	12408823



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