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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 16509579 are 22
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2263	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate	0 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	0 Phosphate	IC-50 = 1.6 nM for target mRNA	16509579
SM2265	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 18,19,20	0 Sugar	IC-50 = 0.088 nM for target mRNA	16509579
SM2266	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 13,14,15	0 Sugar	IC-50 = 14 nM for target mRNA	16509579
SM2267	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 12,13,14	0 Sugar	IC-50 = 0.48 nM for target mRNA	16509579
SM2268	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 16,18,19,20	0 Sugar	IC-50 = 1.1 nM for target mRNA	16509579
SM2269	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 20	0 Sugar	IC-50 = 0.24 nM for target mRNA	16509579
SM2270	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 7,8,9	0 Sugar	IC-50 = 41.5 nM for target mRNA	16509579
SM2271	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,3	0 Sugar	IC-50 = 0.45 nM for target mRNA	16509579
SM2272	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,3,5,16,18,19,20	0 Sugar	IC-50 = 5.9 nM for target mRNA	16509579
SM2274	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	0 4-Thioribose	0 1,2,18,19	0 Sugar	IC-50 = 1.2 nM for target mRNA	16509579
SM2275	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 0	4,10,11,17 0	Sugar 0	IC-50 = 1.1 nM for target mRNA	16509579
SM2276	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 0	1,2,18,19 0	Sugar 0	IC-50 = 0.28 nM for target mRNA	16509579
SM2277	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose Phosphorothioate	4,10,11,17 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18	Sugar Phosphate	IC-50 = 2.4 nM for target mRNA	16509579
SM2278	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose Phosphorothioate	1,2,18,19 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18	Sugar Phosphate	IC-50 = 1.4 nM for target mRNA	16509579
SM2279	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose	4,10,11,17 1,2,18,19	Sugar Sugar	IC-50 = 1.7 nM for target mRNA	16509579
SM2280	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose	1,2,18,19 1,2,18,19	Sugar Sugar	IC-50 = 0.21 nM for target mRNA	16509579
SM2281	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	2-O-(2-Methoxyethyl) 0	1,2,3,17,18,19 0	Sugar 0	IC-50 = 0.58 nM for target mRNA	16509579
SM2282	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	2-O-(2-Methoxyethyl) 4-Thioribose	1,2,3,17,18,19 1,2,18,19	Sugar Sugar	IC-50 = 0.66 nM for target mRNA	16509579
SM2283	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	0 4-Thioribose* 2-O-Methyl	0 1,2 * 17,18,19	0 Sugar	IC-50 = 0.78 nM for target mRNA	16509579
SM2284	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	2-O-(2-Methoxyethyl) 4-Thioribose* 2-O-Methyl	1,2,3,17,18,19 1,2 * 17,18,19	Sugar Sugar	IC-50 = 0.2 nM for target mRNA	16509579
SM2285	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose* 2-O-Methyl	4,10,11,17 1,2 * 17,18,19	Sugar Sugar	IC-50 = 1.9 nM for target mRNA	16509579
SM2286	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose 4-Thioribose* 2-O-Methyl	1,2,18,19 1,2 * 17,18,19	Sugar Sugar	IC-50 = 0.15 nM for target mRNA	16509579