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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 17284457 are 17
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3091
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    16,17
    0
    Sugar
    0
    IC-50 = 0.1 nM for target mRNA
    17284457
    SM3092
    GCUUGAAGUCUUUAATTAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    16,17
    0
    Sugar
    0
    IC-50 = 0.2 nM for target mRNA
    17284457
    SM3093
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    13
    0
    Sugar
    IC-50 = 0.17 nM for target mRNA
    17284457
    SM3094
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACTUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    13
    0
    Sugar
    IC-50 = 0.31 nM for target mRNA
    17284457
    SM3095
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 3.6 nM for target mRNA
    17284457
    SM3096
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 0.16 nM for target mRNA
    17284457
    SM3097
    GCUUGAAGUCUUUAAUUAATT
    TTAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 1 nM for target mRNA
    17284457
    SM3098
    GCUUGAAGUCUUUAAUUAATT
    TTAAUUAAAGACUUCAAGCGG
    0
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2
    0
    Sugar
    IC-50 = 0.04 nM for target mRNA
    17284457
    SM3101
    GCTTGAAGTCTTTAATTAAGG
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    0
    Sugar
    0
    IC-50 = 7.8 nM for target mRNA
    17284457
    SM3102
    GCTTGAAGTCTTTAATTAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,20,21
    0
    Sugar
    0
    IC-50 = 2.4 nM for target mRNA
    17284457
    SM3103
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3104
    GCTTGAAGTCTTTAATTAAGG
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    13
    Sugar
    Sugar
    IC-50 = 17 nM for target mRNA
    17284457
    SM3105
    GCTTGAAGTCTTTAATTAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,20,21
    13
    Sugar
    Sugar
    IC-50 = 0.6 nM for target mRNA
    17284457
    SM3106
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    13
    Sugar
    Sugar
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3107
    GCTTGAAGTCTTTAATTAAGG
    UUAAUUAAAGACTUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoroarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    13
    Sugar
    Sugar
    IC-50 = 10.8 nM for target mRNA
    17284457
    SM3108
    GCTTGAAGTCTTTAATTAATT
    UUAAUUAAAGACTUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoroarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,20,21
    13
    Sugar
    Sugar
    IC-50 = 0.87 nM for target mRNA
    17284457
    SM3109
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACTUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    2-Deoxy-2-Fluoroarabinonucleic acid
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    13
    Sugar
    Sugar
    IC-50 (Greater than 20 nM) for target mRNA
    17284457