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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 2-Fluoro are 20
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2193	GCAGCACGACUUCUUCAAGUU CUUGAAGAAGUCGUGCUGCUU	0 2-Fluoro	0 2	0 Sugar	73.84 percent target mRNA inhibition	18575806
SM2196	GCAGCACGACUUCUUCAAGUU CUUGAAGAAGUCGUGCUGCUU	Locked nucleic acid 2-Fluoro	1 2	Sugar Sugar	69.33 percent target mRNA inhibition	18575806
SM2199	GCAGCACGACUUCUUCAAGUU UUCGUCGUGCUGAAGAAGUUC	2-O-Methyl 2-Fluoro	2 2	Sugar Sugar	77.23 percent target mRNA inhibition	18575806
SM2201	UAGUUCUGUGGGGCUGUUUUU AAACAGCCCCACAGAACUAUU	Locked nucleic acid 2-Fluoro	1 2	Sugar Sugar	NA	18575806
SM2202	UAGUUCUGUGGGGCUGUUUUU AAACAGCCCCACAGAACUAUU	2-O-Methyl 2-Fluoro	2 2	Sugar Sugar	NA	18575806
SM2256	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	2-O-Methyl 2-Fluoro	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 1,7,13,14,15,16,17,18,19	Sugar Sugar	71 percent target mRNA inhibition	16598842
SM2488	CAGCAAACCACGAUCAAUATT UAUUGAUCGUGGUUUGCUGTT	2-Fluoro 2-Fluoro	1,4,8,9,11,14,15,18 1,3,4,7,8,10,13,14,15,17,18	Sugar Sugar	71 percent target mRNA inhibition	22889374
SM2491	CAGAGCAAUUGUUUACCUATT UAGGUAAACAAUUGCUCUGTT	2-Fluoro 2-Fluoro	1,6,9,10,12,13,14,16,17,18 1,5,9,12,13,15,16,17	Sugar Sugar	72 percent target mRNA inhibition	22889374
SM2977	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	0 2-Fluoro	0 1,2,3,11,12,14,16,17,19	0 Sugar	83 percent target mRNA inhibition	12923253
SM2979	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Fluoro 2-Fluoro	2,5,7,10,11,12,13,14,15,16 1,2,3,11,12,14,16,17,19	Sugar Sugar	83 percent target mRNA inhibition	12923253
SM3140	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	0 2-Fluoro	0 8,9,10,11,13,14,17,18,19,20,23,25,26	0 Sugar	85 percent target mRNA inhibition	18637735
SM3141	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-Fluoro 2-Fluoro	2,4,5,10,11,14,19,20 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	85 percent target mRNA inhibition	18637735
SM3143	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-O-Methyl 2-Fluoro	1,3,6,7,8,9,12,13,15,16,17,18 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	14 percent target mRNA inhibition	18637735
SM3158	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	0 2-Fluoro	0 8,9,10,11,13,14,17,18,19,20,23,25,26	0 Sugar	88 percent target mRNA inhibition	18637735
SM3159	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-Fluoro 2-Fluoro	2,4,5,10,11,14,19,20 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	78 percent target mRNA inhibition	18637735
SM3161	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-O-Methyl 2-Fluoro	1,3,6,7,8,9,12,13,15,16,17,18 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	30 percent target mRNA inhibition	18637735
SM3176	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	0 2-Fluoro	0 8,9,10,11,13,14,17,18,19,20,23,25,26	0 Sugar	14 percent target mRNA inhibition	18637735
SM3177	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-Fluoro 2-Fluoro	2,4,5,10,11,14,19,20 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	0 percent target mRNA inhibition	18637735
SM3179	GCACCAGAGCCAAUGGAACUUGATG CAUCAAGUUCCAUUGGCUCUGGUGCUU	2-O-Methyl 2-Fluoro	1,3,6,7,8,9,12,13,15,16,17,18 8,9,10,11,13,14,17,18,19,20,23,25,26	Sugar Sugar	0 percent target mRNA inhibition	18637735
SM3395	CCACCACAGCUAGAACUUA GGUGGUGUCGAUCUUGAAU	2-Fluoro 2-Fluoro	2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19	Sugar Sugar	NA	16625242