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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

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• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Phosphorothioate are 41
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM2240	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	Phosphorothioate Phosphorothioate	2,3,4 2,3,4	Phosphate Phosphate	75 percent target mRNA inhibition	16598842
SM2241	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	Phosphorothioate Phosphorothioate	17,18,19 17,18,19	Phosphate Phosphate	79 percent target mRNA inhibition	16598842
SM2242	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	Phosphorothioate Phosphorothioate	2,3,4,17,18,19 2,3,4,17,18,19	Phosphate Phosphate	78 percent target mRNA inhibition	16598842
SM2252	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	Phosphorothioate Phosphorothioate	2,4,6,8,10,12,14,16,18 2,4,6,8,10,12,14,16,18	Phosphate Phosphate	74 percent target mRNA inhibition	16598842
SM2254	AAGGAGAUCAACAUUUUCATT UGAAAAUGUUGAUCUCCUUTT	2-O-Methyl Phosphorothioate	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	Sugar Phosphate	76 percent target mRNA inhibition	16598842
SM2263	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate	0 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	0 Phosphate	IC-50 = 1.6 nM for target mRNA	16509579
SM2277	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose Phosphorothioate	4,10,11,17 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18	Sugar Phosphate	IC-50 = 2.4 nM for target mRNA	16509579
SM2278	AAGUAAGGACCAGAGACAA UUGUCUCUGGUCCUUACUU	4-Thioribose Phosphorothioate	1,2,18,19 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18	Sugar Phosphate	IC-50 = 1.4 nM for target mRNA	16509579
SM2941	AAGCUGACCCUGAAGUUCAUCUGCACC GGUGCAGAUGAACUUCAGGGUCAGCUU	Phosphorothioate Phosphorothioate	2,27 2,27	Phosphate Phosphate	95 percent target mRNA inhibition	21739319
SM2942	AAGCUGACCCUGAAGUUCAUCUGCACC GGUGCAGAUGAACUUCAGGGUCAGCUU	Phosphorothioate Phosphorothioate	2,3,4,25,26,27 2,3,4,25,26,27	Phosphate Phosphate	93 percent target mRNA inhibition	21739319
SM2947	AAGCUGACCCUGAAGUUCAUCUGCACC GGUGCAGAUGAACUUCAGGGUCAGCUU	Phosphorothioate Phosphorothioate	2,27 2,27	Phosphate Phosphate	93 percent target mRNA inhibition	21739319
SM2948	AAGCUGACCCUGAAGUUCAUCUGCACC GGUGCAGAUGAACUUCAGGGUCAGCUU	Phosphorothioate Phosphorothioate	2,3,4,25,26,27 2,3,4,25,26,27	Phosphate Phosphate	93 percent target mRNA inhibition	21739319
SM2990	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	0 Phosphorothioate	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	0 Phosphate	42 percent target mRNA inhibition	12923253
SM2992	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	Phosphorothioate Phosphorothioate	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19	Phosphate Phosphate	47 percent target mRNA inhibition	12923253
SM3021	GUUCACCUUGAUGCCGUUCUU GAACGGCAUCAAGGUGAACUU	0 Phosphorothioate	0 4,7,10,19	0 Phosphate	58 percent target mRNA inhibition	15545637
SM3023	GUUCACCUUGAUGCCGUUCUU GAACGGCAUCAAGGUGAACUU	0 Phosphorothioate	0 9,15,20,21	0 Phosphate	63 percent target mRNA inhibition	15545637
SM3351	AGACGAGCUGAGCGAGAAGTT TTUCUGCUCGACUCGCUCUUC	Phosphorothioate Phosphorothioate	1,2,20,21 1,2,20,21	Phosphate Phosphate	NA	12834349
SM3352	AGACGAGCUGAGCGAGAAGTT TTUCUGCUCGACUCGCUCUUC	Phosphorothioate Phosphorothioate	1,2,3,4,18,19,20,21 1,2,3,4,18,19,20,21	Phosphate Phosphate	NA	12834349
SM3353	AGACGAGCUGAGCGAGAAGTT TTUCUGCUCGACUCGCUCUUC	Phosphorothioate Phosphorothioate	1,2,3,4,5,6,15,16,17,18,19,20,21 1,2,3,4,5,6,15,16,17,18,19,20,21	Phosphate Phosphate	NA	12834349
SM3354	AGACGAGCUGAGCGAGAAGTT TTUCUGCUCGACUCGCUCUUC	Phosphorothioate Phosphorothioate	1,2,3,4,5,6,7,8,14,15,16,17,18,19,20,21 1,2,3,4,5,6,7,8,14,15,16,17,18,19,20,21	Phosphate Phosphate	NA	12834349
SM3355	AGACGAGCUGAGCGAGAAGTT TTUCUGCUCGACUCGCUCUUC	Phosphorothioate Phosphorothioate	1,2,3,4,5,6,7,8,9,10,11,12,13,14,14,15,16,17,18,19,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21	Phosphate Phosphate	NA	12834349
SM3433	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate	0 1	0 Sugar	IC-50 = 460 nM for target mRNA	US8394947, EP1765074B1
SM4298	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate	0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21	0 Sugar	30 percent target mRNA inhibition	15974578
SM4363	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	2-O-(2-methoxyethyl)ribose Phosphorothioate	1,2,3 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20	Sugar Phosphate	56 percent target mRNA inhibition	15974578
SM4364	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	2-O-(2-methoxyethyl)ribose Phosphorothioate	6,7,8 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20	Sugar Phosphate	45 percent target mRNA inhibition	15974578



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