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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 1 * 20,21 are 23
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM4292	AACCUUACCCACCUCAUGUAUCU AUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid Phosphate* Serinol nucleic acid	1,2,22,23 1 * 20,21	Sugar Sugar	78 percent target mRNA inhibition	25233814
SM4296	AACCUUACCCACCUCAUGUAUCU AUACAUGAGGUGGGUAAGGUU	Serinol nucleic acid Phosphate* Serinol nucleic acid	1,2,22,23 1 * 20,21	Sugar Sugar	0 percent target mRNA inhibition	25233814
SM4485	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	67 percent target mRNA inhibition	12408823
SM4486	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	8 percent target mRNA inhibition	12408823
SM4487	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 5-Amino* 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	18 percent target mRNA inhibition	12408823
SM4493	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	91 percent target mRNA inhibition	12408823
SM4494	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	8 percent target mRNA inhibition	12408823
SM4495	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 5-Amino* 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	25 percent target mRNA inhibition	12408823
SM4501	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	83 percent target mRNA inhibition	12408823
SM4502	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	2-Deoxythymidine 5-Amino* 2-Deoxythymidine	20,21 1 * 20,21	Sugar Phosphate; Sugar	17 percent target mRNA inhibition	12408823
SM4503	GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT	5-Amino* 2-Deoxythymidine 5-Amino* 2-Deoxythymidine	1 * 20,21 1 * 20,21	Phosphate; Sugar Phosphate; Sugar	20 percent target mRNA inhibition	12408823
SM5318	CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU	Inverted abasic* 2-Methoxy 5-hydroxy ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.3 nM for target mRNA	22400991
SM5319	CAAGUGUCAUCACACUGAAUU UUCAGUGUGAUGACACUUGUU	Inverted abasic* 2-Methoxy 5-hydroxy ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.5 nM for target mRNA	22400991
SM5320	CAUUGAACCCAAAUUUGAUUU AUCAAAUUUGGGUUCAAUGUU	Inverted abasic* 2-Methoxy 5-hydroxy ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.05 nM for target mRNA	22400991
SM5321	CAGUCAGCAAAGACGUCUAUU UAGACGUCUUUGCUGACUGUU	Inverted abasic* 2-Methoxy 5-hydroxy ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.13 nM for target mRNA	22400991
SM5322	AUAAGGCUAUGAAGAGAUATT UAUCUCUUCAUAGCCUUAUTT	Inverted abasic* 2-Deoxy 5-hydroxy ribose* 2-Deoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.19 nM for target mRNA	22400991
SM5323	AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU	Inverted abasic* 2-Methoxy 5-hydroxy ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.02 nM for target mRNA	22400991
SM5324	CUUUAACAAUUCCUGAAAUUU AUUUCAGGAAUUGUUAAAGUU	Inverted abasic* 2-Methoxy 5-phosphate ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.44 nM for target mRNA	22400991
SM5325	CAAGUGUCAUCACACUGAAUU UUCAGUGUGAUGACACUUGUU	Inverted abasic* 2-Methoxy 5-phosphate ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.51 nM for target mRNA	22400991
SM5326	CAUUGAACCCAAAUUUGAUUU AUCAAAUUUGGGUUCAAUGUU	Inverted abasic* 2-Methoxy 5-phosphate ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.05 nM for target mRNA	22400991
SM5327	CAGUCAGCAAAGACGUCUAUU UAGACGUCUUUGCUGACUGUU	Inverted abasic* 2-Methoxy 5-phosphate ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.14 nM for target mRNA	22400991
SM5328	AUAAGGCUAUGAAGAGAUATT UAUCUCUUCAUAGCCUUAUTT	Inverted abasic* 2-Deoxy 5-phosphate ribose* 2-Deoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.6 nM for target mRNA	22400991
SM5329	AAAUCAUGGUGAAAUAAAAUU UUUUAUUUCACCAUGAUUUUU	Inverted abasic* 2-Methoxy 5-phosphate ribose* 2-Methoxy	1,21 * 20,21 1 * 20,21	Base; Sugar Sugar	EC-50 = 0.02 nM for target mRNA	22400991