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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 634
    Results from 575 - 600
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4768
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Locked nucleic acid* 2-O-Methylribose
    0
    5,8,11,14 * 17,18,19
    0
    Sugar; Sugar
    IC-50 = 0.022046 nM for target mRNA
    US 8394947 B2
    SM4769
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Phosphorothioate
    0
    3,9,12,17,18,19
    0
    Phosphate-linkage
    IC-50 = 0.491 nM for target mRNA
    US 8394947 B2
    SM4770
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Phosphorothioate
    0
    3,9,12,17,18,19
    0
    Phosphate-linkage
    IC-50 = 0.46 nM for target mRNA
    US 8394947 B2
    SM4771
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    18,19,20
    0
    Phosphate-linkage
    IC-50 = 0.273 nM for target mRNA
    US 8394947 B2
    SM4772
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    16,18,19,20
    0
    Phosphate-linkage
    IC-50 = 0.363 nM for target mRNA
    US 8394947 B2
    SM4773
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    20
    0
    Phosphate-linkage
    IC-50 = 0.131 nM for target mRNA
    US 8394947 B2
    SM4774
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    13,14,15
    0
    Phosphate-linkage
    IC-50 = 0.428 nM for target mRNA
    US 8394947 B2
    SM4775
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    12,13,14
    0
    Phosphate-linkage
    IC-50 = 0.122 nM for target mRNA
    US 8394947 B2
    SM4776
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    8,9,10
    0
    Phosphate-linkage
    IC-50 = 7.08 nM for target mRNA
    US 8394947 B2
    SM4777
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate
    0
    1,2,3
    0
    Phosphate-linkage
    IC-50 = 0.144 nM for target mRNA
    US 8394947 B2
    SM4778
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    2-O-Methylribose
    0
    15,16,17,18,19
    0
    Phosphate-linkage
    IC-50 = 0.031541 nM for target mRNA
    US 8394947 B2
    SM4779
    AAGUAAGGACCAGAGACAAA
    UUTGTCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-methoxyethylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 3,4,5
    0
    Phosphate-linkage; Sugar
    IC-50 = 29.4 nM for target mRNA
    US 8394947 B2
    SM4780
    AAGUAAGGACCAGAGACAAA
    TTTGTCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose* Phosphorothioate
    0
    1,2,3 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar; Sugar
    IC-50 = 3.39 nM for target mRNA
    US 8394947 B2
    SM4781
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 15,16,17
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.3 nM for target mRNA
    US 8394947 B2
    SM4782
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 12,13,14
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.30815 nM for target mRNA
    US 8394947 B2
    SM4783
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 6,7,8
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.5416 nM for target mRNA
    US 8394947 B2
    SM4784
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 18,19,20
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.0933 nM for target mRNA
    US 8394947 B2
    SM4785
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-Deoxy-2-fluororibose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.68552 nM for target mRNA
    US 8394947 B2
    SM4786
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,9,12 * 17,18,19
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.13216. nM for target mRNA
    US 8394947 B2
    SM4788
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,10,19
    0
    Sugar
    81.7 percent target mRNA inhibition
    US 8394947 B2
    SM4789
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    56.2 percent target mRNA inhibition
    US 8394947 B2
    SM4790
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    60.8 percent target mRNA inhibition
    US 8394947 B2
    SM4791
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,8,16
    0
    Sugar
    57 percent target mRNA inhibition
    US 8394947 B2
    SM4792
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,11,19
    0
    Sugar
    85 percent target mRNA inhibition
    US 8394947 B2
    SM4793
    AAGUAAGGACCAGAGACAA
    UUUGUCUCUGGUCCUUACUU
    0
    2-O-methoxyethylribose
    0
    4,10,19
    0
    Sugar
    83 percent target mRNA inhibition
    US 8394947 B2