SATPdb: It is an integrated peptide database containing peptides collected from 20 databases and 2 peptide datasets available in the public domain. It links all the databases in such a way that it makes easy to search different properties for a peptide query.

Peptide sequences: The SATPdb contains peptides with different functional properties like anti-microbial peptides (AMP), anti-parasitic, anti-cancer, hemolytic, tumor homing, cell-penetrating, etc.

Type of Peptides: SATPdb consists of various types of peptides, which includes linear peptides, cyclic peptides and peptides having L-amino acids, non-natural amino acids (e.g., D-amino acid, ornithine, norleucine, etc.) and chemically modified residues.

Web Tools: We integrated various tools for similarity search (like BLAST) and Peptide Mapping, to effectively search the SATPdb database

Structure of Peptides: We predicted the tertiary structure of each peptide in SATPdb using PEPStrMOD software. First, we scan PDB to identify all identical peptides to assign their tertiary structure. Structure of remaining peptides were predicted using PEPstrMOD. Secondary structure of peptides were assigned using DSSP from their tertiary structure.

Following are the salient features of SATPdb database:

  • Moonlighting Peptides: It allow users to identify moonligting peptides having multiple functions, for example identification of peptide having anti-cancer, anti-viral and cell-penetration ability.
  • Therapeutic Peptides: Identification of peptides having desired therapeutic potential but minimum or no side effects (e.g., RBC hemolysis).
  • Similar Peptides: It allow users to identify similar or idential peptides where similarity of peptides may be based on their primary or secondary or tertiary structure.