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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 12408823 are 24
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4484
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    62 percent target mRNA inhibition
    12408823
    SM4485
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    67 percent target mRNA inhibition
    12408823
    SM4486
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    20,21
    1 * 20,21
    Sugar
    Phosphate; Sugar
    8 percent target mRNA inhibition
    12408823
    SM4487
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    18 percent target mRNA inhibition
    12408823
    SM4488
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    83 percent target mRNA inhibition
    12408823
    SM4489
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Puromycin
    20,21
    20,21 * 21
    Sugar
    Sugar
    67 percent target mRNA inhibition
    12408823
    SM4490
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine* Puromycin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    50 percent target mRNA inhibition
    12408823
    SM4491
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Biotin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    61 percent target mRNA inhibition
    12408823
    SM4492
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    12408823
    SM4493
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    91 percent target mRNA inhibition
    12408823
    SM4494
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    20,21
    1 * 20,21
    Sugar
    Phosphate; Sugar
    8 percent target mRNA inhibition
    12408823
    SM4495
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    25 percent target mRNA inhibition
    12408823
    SM4496
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    85 percent target mRNA inhibition
    12408823
    SM4497
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Puromycin
    20,21
    20,21 * 21
    Sugar
    Sugar
    76 percent target mRNA inhibition
    12408823
    SM4498
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine* Puromycin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    73 percent target mRNA inhibition
    12408823
    SM4499
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Biotin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    95 percent target mRNA inhibition
    12408823
    SM4500
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    78 percent target mRNA inhibition
    12408823
    SM4501
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    83 percent target mRNA inhibition
    12408823
    SM4502
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    20,21
    1 * 20,21
    Sugar
    Phosphate; Sugar
    17 percent target mRNA inhibition
    12408823
    SM4503
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    5-Amino* 2-Deoxythymidine
    5-Amino* 2-Deoxythymidine
    1 * 20,21
    1 * 20,21
    Phosphate; Sugar
    Phosphate; Sugar
    20 percent target mRNA inhibition
    12408823
    SM4504
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    69 percent target mRNA inhibition
    12408823
    SM4505
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Puromycin
    20,21
    20,21 * 21
    Sugar
    Sugar
    62 percent target mRNA inhibition
    12408823
    SM4506
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine* Puromycin
    2-Deoxythymidine* Puromycin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    56 percent target mRNA inhibition
    12408823
    SM4507
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxythymidine
    2-Deoxythymidine* Biotin
    1 * 20,21
    20,21 * 21
    Phosphate; Sugar
    Sugar
    86 percent target mRNA inhibition
    12408823