Browse By

Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for US 8394947 B2 are 57
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4746
    CAUUGGUGAAGGAUCCAGGA
    UCCUGGAUCCUUCACCAAUG
    0
    2-O-Methylribose
    0
    6,12,15,18,19,20
    0
    Sugar
    IC-50 = 0.022859 nM for target mRNA
    US 8394947 B2
    SM4747
    CAUUGGUGAAGGAUCCAGGA
    CCUGGAUCCUUCACCAAUG
    0
    2-O-Methylribose
    0
    5,6,9,10,17,18,19
    0
    Sugar
    IC-50 = 0.01205 nM for target mRNA
    US 8394947 B2
    SM4748
    AGAAGACACCUUCUGAGUAU
    AUACUCAGAAGGUGUCUUCU
    0
    2-O-Methylribose
    0
    6,7,10,11,18,19,20
    0
    Sugar
    IC-50 = 0.075517 nM for target mRNA
    US 8394947 B2
    SM4749
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    2-O-Methylribose
    0
    5,8,11,14,17,18,19
    0
    Sugar
    IC-50 = 0.17024 nM for target mRNA
    US 8394947 B2
    SM4750
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    2-O-Methylribose
    0
    6,7,10,11,17,18,19
    0
    Sugar
    IC-50 = 0.055386 nM for target mRNA
    US 8394947 B2
    SM4751
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    4-Thioribose* Phosphorothioate
    2-O-Methylribose
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
    6,7,10,11,17,18,19
    Sugar; Phosphate-linkage
    Sugar
    IC-50 = 0.11222 nM for target mRNA
    US 8394947 B2
    SM4752
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    4-Thioribose* Phosphorothioate
    2-O-Methylribose
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
    5,8,11,14,17,18,19
    Sugar; Phosphate-linkage
    Sugar
    IC-50 = 0.96445 nM for target mRNA
    US 8394947 B2
    SM4753
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-Methylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,18
    5,8,11,14,17,18,20
    Sugar
    Sugar
    IC-50 = 0.21527 nM for target mRNA
    US 8394947 B2
    SM4754
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-Methylribose
    2-O-Methylribose
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18
    5,8,11,14,17,18,21
    Sugar
    Sugar
    IC-50 = 0.12453 nM for target mRNA
    US 8394947 B2
    SM4755
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-Methylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,18
    6,7,10,11,17,18,19
    Sugar
    Sugar
    IC-50 = 0.045167 nM for target mRNA
    US 8394947 B2
    SM4756
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-methoxyethylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,18
    5,8,11,14,17,18,19
    Sugar
    Sugar
    IC-50 = 0.47593 nM for target mRNA
    US 8394947 B2
    SM4757
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-methoxyethylribose
    2-O-Methylribose
    2,4,6,8,10,12,14,16,19
    6,7,10,11,17,18,19
    Sugar
    Sugar
    IC-50 = 0.11759 nM for target mRNA
    US 8394947 B2
    SM4758
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    2-O-Methlyribose
    2-O-Methylribose
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    5,8,11,14,17,18,19
    Sugar
    Sugar
    IC-50 = 0.075608 nM for target mRNA
    US 8394947 B2
    SM4759
    AGAAGACACCUUCUGAGUAU
    AUACUCAGAAGGUGUCUUCU
    2-O-Methylribose
    2-O-Methylribose
    2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,20
    6,7,10,11,18,19,20
    Sugar
    Sugar
    IC-50 = 0.025677 nM for target mRNA
    US 8394947 B2
    SM4760
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* 2-O-Methylribose
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.809 nM for target mRNA
    US 8394947 B2
    SM4761
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    4-Thioribose* Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 6,7,8
    0
    Phosphate-linkage; Sugar
    IC-50 = 1.57 nM for target mRNA
    US 8394947 B2
    SM4762
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Locked nucleic acid
    0
    1,2,3,6,9,12,15,18,19,20
    0
    Sugar
    IC-50 = 0.769 nM for target mRNA
    US 8394947 B2
    SM4763
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Locked nucleic acid* Phosphorothioate
    0
    1,2,3 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar; Phosphate-linkage
    IC-50 = 18.4 nM for target mRNA
    US 8394947 B2
    SM4764
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Locked nucleic acid* Phosphorothioate
    0
    4,9,19 * 4,9,19
    0
    Sugar; Phosphate-linkage
    IC-50 = 0.020825 nM for target mRNA
    US 8394947 B2
    SM4765
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 9,10,11
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.5627 nM for target mRNA
    US 8394947 B2
    SM4766
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 18,19,20
    0
    Phosphate-linkage; Sugar
    IC-50 = 0.27688 nM for target mRNA
    US 8394947 B2
    SM4767
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    0
    Phosphorothioate* Locked nucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19* 19
    0
    Phosphate-linkage; Sugar
    IC-50 = 5.58 nM for target mRNA
    US 8394947 B2
    SM4768
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Locked nucleic acid* 2-O-Methylribose
    0
    5,8,11,14 * 17,18,19
    0
    Sugar; Sugar
    IC-50 = 0.022046 nM for target mRNA
    US 8394947 B2
    SM4769
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Phosphorothioate
    0
    3,9,12,17,18,19
    0
    Phosphate-linkage
    IC-50 = 0.491 nM for target mRNA
    US 8394947 B2
    SM4770
    GGAGAUCAACAUUUUCAAA
    UUUGAAAAUGUUGAUCUCC
    0
    Phosphorothioate
    0
    3,9,12,17,18,19
    0
    Phosphate-linkage
    IC-50 = 0.46 nM for target mRNA
    US 8394947 B2