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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 200 - 225
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2826
    CUCACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Mutation* 2-O-Methyl* Phosphorothioate* 2,4-Difluorotoluene
    0
    3 * 9 * 9 * 10
    0
    Sugar; Phosphate; Base
    0
    IC-50 = 0.111 nM for target mRNA
    20610434
    SM2828
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2-O-Methyl
    0
    9
    0
    Sugar
    0
    IC-50 = 0.146 nM for target mRNA
    20610434
    SM2829
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2-O-Methyl* Phosphorothioate
    0
    9
    0
    Sugar; Phosphate
    0
    IC-50 = 0.129 nM for target mRNA
    20610434
    SM2830
    CUUACGCUGAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    2,4-Difluorotoluene
    0
    10
    0
    Base
    0
    IC-50 = 0.056 nM for target mRNA
    20610434
    SM2831
    CUUACGCUGAAGUACUUCGAAA
    UCGAAGUACUCAGCGUAAGUG
    Phosphorothioate* 2,4-Difluorotoluene
    0
    9 * 10
    0
    Phosphate; Base
    0
    IC-50 = 0.052 nM for target mRNA
    20610434
    SM2844
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    9
    0
    Base
    0
    IC-50 = 0.031 nM for target mRNA
    20610434
    SM2845
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    10
    0
    Base
    0
    IC-50 = 0.04 nM for target mRNA
    20610434
    SM2846
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    11
    0
    Base
    0
    IC-50 = 0.039 nM for target mRNA
    20610434
    SM2847
    AAGUAAGGACCAGAGACAATT
    UUGUCUCUGGUCCUUACUUTT
    2,4-difluorotoluene ribonucleotide
    0
    12
    0
    Base
    0
    IC-50 = 0.027 nM for target mRNA
    20610434
    SM2978
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Fluoro
    0
    2,5,7,10,11,12,13,14,15,16
    0
    Sugar
    0
    92 percent target mRNA inhibition
    12923253
    SM2985
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    38 percent target mRNA inhibition
    12923253
    SM2988
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    25 percent target mRNA inhibition
    12923253
    SM2991
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Phosphorothioate
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Phosphate
    0
    62 percent target mRNA inhibition
    12923253
    SM3017
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Phosphorothioate
    0
    4,6,7,14,15,19
    0
    Phosphate
    0
    85 percent target mRNA inhibition
    15545637
    SM3018
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Boranophosphate
    0
    4,6,7,14,15,19
    0
    Phosphate
    0
    98 percent target mRNA inhibition
    15545637
    SM3019
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Phosphorothioate
    0
    2,3,8,9,12,17,18,20,21
    0
    Phosphate
    0
    45 percent target mRNA inhibition
    15545637
    SM3020
    GUUCACCUUGAUGCCGUUCUU
    GAACGGCAUCAAGGUGAACUU
    Boranophosphate
    0
    2,3,8,9,12,17,18,20,21
    0
    Phosphate
    0
    70 percent target mRNA inhibition
    15545637
    SM3034
    GUUCACCUUGAUGCCGUUCUU
    GCACGACUUCUUCAAGUCCUU
    Boranophosphate
    0
    3,8,9,11,12
    0
    Phosphate
    0
    58 percent target mRNA inhibition
    15545637
    SM3035
    GUUCACCUUGAUGCCGUUCUU
    GCACGACUUCUUCAAGUCCUU
    Boranophosphate
    0
    5,6,14,20,21
    0
    Phosphate
    0
    73 percent target mRNA inhibition
    15545637
    SM3046
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid
    0
    20,21
    0
    Sugar
    0
    97 percent target mRNA inhibition
    15653644
    SM3048
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,20,22 * 1
    0
    Sugar; Base
    0
    97 percent target mRNA inhibition
    15653644
    SM3050
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,2,3,8,12,15,16,20,21 * 1
    0
    Sugar; Base
    0
    81 percent target mRNA inhibition
    15653644
    SM3062
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    74 percent target mRNA inhibition
    15653644
    SM3063
    TGAGAGAAAGCACAGAAAATT
    UUUUCUGUGCUUUCUCUCATT
    Locked nucleic acid
    0
    1,3,5,9,12,14,17,20,21
    0
    Sugar
    0
    68 percent target mRNA inhibition
    15653644
    SM3066
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    82 percent target mRNA inhibition
    15653644