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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 75 - 100
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2471
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 2,3,4,14,15,16,17 * 15,16,17
    0
    Phosphate; Base; Phosphate
    0
    48 percent target mRNA inhibition
    23135004
    SM2472
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* 2-O-Methyl* Fluorouridine* Phosphorothioate
    0
    1 * 1,2,3 * 15,16,17 * 19
    0
    Phosphate; Sugar; Base; Phosphate
    0
    58 percent target mRNA inhibition
    23135004
    SM2473
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 6,11,15,16,17 *19
    0
    Phosphate; Base; Phosphate
    0
    37 percent target mRNA inhibition
    23135004
    SM2474
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 15,16,17 * 1,2,19
    0
    Phosphate; Base; Phosphate
    0
    43 percent target mRNA inhibition
    23135004
    SM2475
    GAGGCUGGGAUGCCUUUTT
    AAAGGCAUCCCAGCCUCCGTT
    Cholesterol* Fluorouridine* Phosphorothioate
    0
    1 * 6,11,15,16,17 * 2,3,19
    0
    Phosphate; Base; Phosphate
    0
    52 percent target mRNA inhibition
    23135004
    SM2479
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Phenyl
    0
    1
    0
    Phosphate
    0
    92 percent target mRNA inhibition
    22982308
    SM2480
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Hydroxyphenyl-Conjugated
    0
    1
    0
    Phosphate
    0
    90 percent target mRNA inhibition
    22982308
    SM2481
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Naphthalene modification
    0
    1
    0
    Sugar
    0
    87 percent target mRNA inhibition
    22982308
    SM2482
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Pyrene modification
    0
    1
    0
    Sugar
    0
    87 percent target mRNA inhibition
    22982308
    SM2483
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Locked nucleic acid
    0
    1
    0
    Sugar
    0
    86 percent target mRNA inhibition
    22982308
    SM2484
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    83 percent target mRNA inhibition
    22982308
    SM2495
    CUCCUUTTGTTTCTGCUAACG
    CGTTUGCAGAAACAAUUGGUG
    2-Deoxyribonucleotide
    0
    7,8,9,10,11,12,13,14,15
    0
    Sugar
    0
    High target mRNA inhibition efficacy
    12771197
    SM2496
    CUCAUUTTCTTTGTGCUCACG
    CGTTUGCAGAAACAAUUGGUG
    2-Deoxyribonucleotide* Inverted abasic (Mutation)
    0
    7,8,9,10,11,12,13,14,15* 1,21 (4,9,13,18)
    0
    Sugar (Base)
    0
    Low mRNA target inhibition efficacy
    12771198
    SM2517
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine* 5-Amino * 3-Amino
    0
    22,23 * 1* 23
    0
    Sugar
    0
    High target mRNA inhibition efficacy
    12771196
    SM2523
    CUCCUUUUGUUUCUGCUAACG
    CGUUAGCAGAAACAAAGGAG
    2-O-Methyl
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    0
    Sugar
    0
    Low mRNA target inhibition efficacy
    12771196
    SM2534
    UCUUGAUGUACUCCCCUCG
    CGAGGGGAGUACAUCAAGA
    2-Deoxythymidine
    0
    1,2
    0
    Sugar
    0
    NA
    12771196
    SM2545
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    10 percent target mRNA inhibition
    17511001
    SM2546
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    45 percent target mRNA inhibition
    17511001
    SM2554
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    51 percent target mRNA inhibition
    17511001
    SM2555
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    68 percent target mRNA inhibition
    17511001
    SM2563
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    64 percent target mRNA inhibition
    17511001
    SM2564
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    82 percent target mRNA inhibition
    17511001
    SM2572
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    2,3,6,7,9,12,13,14,15,16,17,18
    0
    Sugar
    0
    83 percent target mRNA inhibition
    17511001
    SM2573
    UGGCCAAUGCCAAGGAGAUUU
    AUCUCCUUGGCAUUGGCCAUU
    2-Deoxy-2-Fluoro
    0
    1,4,5,8,10,11,19,20,21
    0
    Sugar
    0
    87 percent target mRNA inhibition
    17511001
    SM2617
    TGUACGCGGAAUACUUCGAUU
    UCGAAGUAUUCCGCGUACGUU
    Mutation* 5-O-Methyl
    0
    1 * 1
    0
    Base; Sugar
    0
    70 percent target mRNA inhibition
    18094121