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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 275 - 300
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3291
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Altritol nucleic acid
    0
    1
    0
    Sugar
    0
    33 percent target mRNA inhibition
    17264131
    SM3292
    GUAUUGACAGCUAUUCGAATT
    UUCGAAUAGCUGUCAAUACTT
    Altritol nucleic acid
    0
    1,2
    0
    Sugar
    0
    36 percent target mRNA inhibition
    17264131
    SM3315
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    Conjugation bulky group
    0
    1
    0
    Phosphate
    0
    25 percent target mRNA inhibition
    19948766
    SM3316
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    Conjugation bulky group
    0
    40
    0
    Sugar
    0
    90 percent target mRNA inhibition
    19948766
    SM3317
    GCACGAAUCCUAAACCUCACAAUAUGAGGUUUAGGAUUCGUGCUU
    0
    Conjugation bulky group
    0
    1
    0
    Phosphate
    0
    60 percent target mRNA inhibition
    19948766
    SM3318
    GCACGAAUCCUAAACCUCACAAUAUGAGGUUUAGGAUUCGUGCUU
    0
    Conjugation bulky group
    0
    40
    0
    Sugar
    0
    40 percent target mRNA inhibition
    19948766
    SM3319
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    20,21
    0
    Sugar
    0
    90 percent target mRNA inhibition
    19948766
    SM3320
    UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    1,3,5,7,9,11,13,15,17,19
    0
    Sugar
    0
    67 percent target mRNA inhibition
    19948766
    SM3322
    UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    1,6,8,14,17
    0
    Sugar
    0
    50 percent target mRNA inhibition
    19948766
    SM3323
    TGAGGTUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-Deoxy
    0
    1,2,3,4,5,6
    0
    Sugar
    0
    70 percent target mRNA inhibition
    19948766
    SM3324
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCTCA
    0
    2-Deoxy
    0
    35,36,37,38,39,40
    0
    Sugar
    0
    88 percent target mRNA inhibition
    19948766
    SM3325
    TGAGGTUUAGGAUUCGUGCUUGCACGAAUCCUAAACCTCA
    0
    2-Deoxy
    0
    1,2,3,4,5,6,35,36,37,38,39,40
    0
    Sugar
    0
    86 percent target mRNA inhibition
    19948766
    SM3326
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    Phosphorothioate
    0
    1,2,39,40
    0
    Phosphate
    0
    93 percent target mRNA inhibition
    19948766
    SM3327
    UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA
    0
    Phosphorothioate
    0
    1,2,39,40
    0
    Phosphate
    0
    87 percent target mRNA inhibition
    19948766
    SM3328
    UGAGGUUUAGGAUUCGUGCTTGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    1,3,5,7,9,11,13,15,17,19
    0
    Sugar
    0
    54 percent target mRNA inhibition
    19948766
    SM3329
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    19,21,23,25,27,29,31,33,35,37,39
    0
    Sugar
    0
    88 percent target mRNA inhibition (IC-50 = 0.0065 nM)
    19948766
    SM3330
    AUUCGUGCUCAUGGUGCACUUGUGCACCAUGAGCACGAAU
    0
    2-O-Methyl
    0
    19,21,23,25,27,29,31,33,35,37,39
    0
    Sugar
    0
    NA
    19948766
    SM3331
    UUUUUCUUUGAGGUUUAGGUUCCUAAACCUCAAAGAAAAA
    0
    2-O-Methyl
    0
    19,21,23,25,27,29,31,33,35,37,39
    0
    Sugar
    0
    NA
    19948766
    SM3332
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    20,21
    0
    Sugar
    0
    87 percent target mRNA inhibition
    19948766
    SM3333
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    2
    0
    Sugar
    0
    70 percent target mRNA inhibition
    19948766
    SM3334
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-O-Methyl
    0
    20,21
    0
    Sugar
    0
    60 percent target mRNA inhibition
    19948766
    SM3335
    GCACGAAUCCUAAACCUCACAAUAUGAGGUUUAGGAUUCGUGCUU
    0
    2-O-Methyl
    0
    25
    0
    Sugar
    0
    74 percent target mRNA inhibition
    19948766
    SM3336
    GCACGAAUCCUAAACCUCACAAUAUGAGGUUUAGGAUUCGUGCUU
    0
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18,25
    0
    Sugar
    0
    57 percent target mRNA inhibition
    19948766
    SM3339
    AUUCGUGCUCAUGGUGCACUUGUGCACCAUGAGCACGAAUTT
    0
    2-O-Methyl
    0
    20,21,23,25,27,29,33,35,37,39
    0
    Sugar
    0
    64 percent target mRNA inhibition
    19948766
    SM3340
    AUUCGUGCUCAUGGUGCACUUGUGCACCAUGAGCACGAAUTT
    0
    2-O-Methyl
    0
    23,39
    0
    Sugar
    0
    NA
    19948766