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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 21985606 are 26
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4453
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    94 percent target mRNA inhibition
    21985606
    SM4454
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Cholesterol
    0
    1
    0
    Phosphate
    0
    83 percent target mRNA inhibition
    21985606
    SM4455
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Lauric acid
    0
    1
    0
    Phosphate
    0
    87 percent target mRNA inhibition
    21985606
    SM4456
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    0
    Palmitic Acid
    0
    21
    0
    Phosphate
    82 percent target mRNA inhibition
    21985606
    SM4458
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    6 percent target mRNA inhibition
    21985606
    SM4459
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Cholesterol
    0
    1
    0
    Phosphate
    0
    42 percent target mRNA inhibition
    21985606
    SM4461
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    83 percent target mRNA inhibition
    21985606
    SM4462
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    54 percent target mRNA inhibition
    21985606
    SM4463
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    90 percent target mRNA inhibition
    21985606
    SM4464
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    65 percent target mRNA inhibition
    21985606
    SM4465
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGATT
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    88 percent target mRNA inhibition
    21985606
    SM4467
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    48 percent target mRNA inhibition
    21985606
    SM4468
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    25 percent target mRNA inhibition
    21985606
    SM4469
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    73 percent target mRNA inhibition
    21985606
    SM4470
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    55 percent target mRNA inhibition
    21985606
    SM4471
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    85 percent target mRNA inhibition
    21985606
    SM4473
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    7 percent target mRNA inhibition
    21985606
    SM4474
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4475
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    18 percent target mRNA inhibition
    21985606
    SM4476
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    12 percent target mRNA inhibition
    21985606
    SM4477
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    1 * 20 * 21
    20 * 21
    Phosphate; Sugar; Sugar
    Sugar
    30 percent target mRNA inhibition
    21985606
    SM4479
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    8 percent target mRNA inhibition
    21985606
    SM4480
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    20,21
    20,21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606
    SM4481
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid* 2-Deoxyribonucleotide
    2-Deoxyribonucleotide
    1 * 20,21
    20,21
    Phosphate; Sugar
    Sugar
    6 percent target mRNA inhibition
    21985606
    SM4482
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    2-Deoxyribonucleotide* Inverted thymidine
    2-Deoxyribonucleotide* Inverted thymidine
    20 * 21
    20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    21985606