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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for US8394947, EP1765074B1 are 29
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM3411	CAUUGGUGAAGGAUCCAGGA UCCUGGAUCCUUCACCAAUG	0 2-O-Methyl* Phosphodiester	0 6,12,15,18,19,20 * 6,12,15,18,19	0 Sugar	IC-50 = 22.859 nM for target mRNA	US8394947, EP1765074B1
SM3412	CAUUGGUGAAGGAUCCAGGA CCUGGAUCCUUCACCAAUG	0 2-O-Methyl* Phosphodiester	0 5,6,9,10,17,18,19 * 5,6,9,10,17,18	0 Sugar	IC-50 = 12.05 nM for target mRNA	US8394947, EP1765074B1
SM3413	AGAAGACACCUUCUGAGUAU AUACUCAGAAGGUGUCUUCU	0 2-O-Methyl* Phosphodiester	0 6,7,10,11,18,19,20 * 6,7,10,11,18,19	0 Sugar	IC-50 = 75.517 nM for target mRNA	US8394947, EP1765074B1
SM3414	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	0 2-O-Methyl* Phosphodiester	0 5,8,11,14,17,18,19 * 5,8,11,14,17,18	0 Sugar	IC-50 = 170.24 nM for target mRNA	US8394947, EP1765074B1
SM3415	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	0 2-O-Methyl* Phosphodiester	0 6,7,10,11,17,18,19 * 6,7,10,11,17,18	0 Sugar	IC-50 = 55.386 nM for target mRNA	US8394947, EP1765074B1
SM3416	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	4’-thioribose* Phosphothioate 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 215.27 nM for target mRNA	US8394947, EP1765074B1
SM3417	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	4’-thioribose* Phosphothioate 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 5,8,11,14,17,18,19 * 5,8,11,14,17,18	Sugar Sugar	IC-50 = 124.53 nM for target mRNA	US8394947, EP1765074B1
SM3418	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	2,4,6,8,10,12,14,16,18 * 2,4,6,8,10,12,14,16,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 45.167 nM for target mRNA	US8394947, EP1765074B1
SM3419	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	2,4,6,8,10,12,14,16,18 * 2,4,6,8,10,12,14,16,18 5,8,11,14,17,18,19 * 5,8,11,14,17,18	Sugar Sugar	IC-50 = 475.93 nM for target mRNA	US8394947, EP1765074B1
SM3420	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	2,4,6,8,10,12,14,16,18 * 2,4,6,8,10,12,14,16,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 117.59 nM for target mRNA	US8394947, EP1765074B1
SM3421	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 5,8,11,14,17,18,19 * 5,8,11,14,17,18	Sugar Sugar	IC-50 = 376 nM for target mRNA	US8394947, EP1765074B1
SM3422	AGAAGACACCUUCUGAGUAU AUACUCAGAAGGUGUCUUCU	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 6,7,10,11,18,19,20 * 6,7,10,11,18,19	Sugar Sugar	IC-50 = 261 nM for target mRNA	US8394947, EP1765074B1
SM3423	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 75.608 nM for target mRNA	US8394947, EP1765074B1
SM3424	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	2-O-Methyl* Phosphodiester 2-O-Methyl* Phosphodiester	2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 25.677 nM for target mRNA	US8394947, EP1765074B1
SM3425	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Locked nucleic acid* Phosphodiester	0 3,8,17 * 3,8,17	0 Sugar	IC-50 = 809 nM for target mRNA	US8394947, EP1765074B1
SM3426	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Locked nucleic acid* Phosphodiester	0 3,4,10,11,17,18 * 3,4,10,11,17,18	0 Sugar	IC-50 = 1570 nM for target mRNA	US8394947, EP1765074B1
SM3427	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Locked nucleic acid* Phosphodiester	0 1,2,3,6,9,12,15,18,19,20 * 1,2,3,6,9,12,15,18,19	0 Sugar	IC-50 = 1130 nM for target mRNA	US8394947, EP1765074B1
SM3428	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	0 Locked nucleic acid* Phosphodiester	0 4,9,18 * 4,9,18	0 Sugar	IC-50 = 769 nM for target mRNA	US8394947, EP1765074B1
SM3429	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	0 Locked nucleic acid* Phosphodiester* 2-O-Methyl	0 5,8,11,14 * 5,8,11,14,18,19 * 16,17,18	0 Sugar	IC-50 = 276.88 nM for target mRNA	US8394947, EP1765074B1
SM3430	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	0 Phosphorothioate* Phosphodiester	0 3,9,12,17,18,19 * 3,9,12,17,18	0 Sugar	IC-50 = 5580 nM for target mRNA	US8394947, EP1765074B1
SM3431	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Phosphodiester	0 18,19,20 * 18,19	0 Sugar	IC-50 = 22.046 nM for target mRNA	US8394947, EP1765074B1
SM3432	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Phosphodiester	0 16,18,19,20 * 16,18,19	0 Sugar	IC-50 = 491 nM for target mRNA	US8394947, EP1765074B1
SM3433	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate	0 1	0 Sugar	IC-50 = 460 nM for target mRNA	US8394947, EP1765074B1
SM3434	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Phosphodiester	0 13,14,15 * 13,14,15	0 Sugar	IC-50 = 273 nM for target mRNA	US8394947, EP1765074B1
SM3435	AAGUAAGGACCAGAGACAAA UUUGUCUCUGGUCCUUACUU	0 Phosphorothioate* Phosphodiester	0 12,13,14 * 12,13,14	0 Sugar	IC-50 = 363 nM for target mRNA	US8394947, EP1765074B1



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