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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 450 - 475
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4356
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    6,7,8
    0
    Sugar
    0
    40 percent target mRNA inhibition
    15974578
    SM4357
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    12,13,14
    0
    Sugar
    0
    65 percent target mRNA inhibition
    15974578
    SM4358
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    18,19,20
    0
    Sugar
    0
    68 percent target mRNA inhibition
    15974578
    SM4359
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    1,2,3
    0
    Sugar
    0
    70 percent target mRNA inhibition
    15974578
    SM4360
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    6,7,8
    0
    Sugar
    0
    70 percent target mRNA inhibition
    15974578
    SM4361
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    12,13,14
    0
    Sugar
    0
    77 percent target mRNA inhibition
    15974578
    SM4362
    AAGUAAGGACCAGAGACAAA
    UUUGUCUCUGGUCCUUACUU
    2-O-(2-methoxyethyl)ribose
    0
    18,19,20
    0
    Sugar
    0
    75 percent target mRNA inhibition
    15974578
    SM4453
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    94 percent target mRNA inhibition
    21985606
    SM4454
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Cholesterol
    0
    1
    0
    Phosphate
    0
    83 percent target mRNA inhibition
    21985606
    SM4455
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Lauric acid
    0
    1
    0
    Phosphate
    0
    87 percent target mRNA inhibition
    21985606
    SM4458
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    6 percent target mRNA inhibition
    21985606
    SM4459
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Cholesterol
    0
    1
    0
    Phosphate
    0
    42 percent target mRNA inhibition
    21985606
    SM4461
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    83 percent target mRNA inhibition
    21985606
    SM4467
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    48 percent target mRNA inhibition
    21985606
    SM4473
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    7 percent target mRNA inhibition
    21985606
    SM4479
    UCCUACAGCACAACAAAUGUG
    CAUUUGUUGUGCUGUAGGAAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    8 percent target mRNA inhibition
    21985606
    SM4534
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide
    0
    24,25
    0
    Sugar
    0
    70 percent target mRNA inhibition
    22236254
    SM4535
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxyribonucleotide* 1-Aminohexane
    0
    24,25 * 25
    0
    Sugar; Phosphate
    0
    79 percent target mRNA inhibition
    22236254
    SM4540
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    1-Aminohexane* 2-Deoxyribonucleotide
    0
    1 * 24,25
    0
    Phosphate; Sugar
    0
    69 percent target mRNA inhibition
    22236254
    SM4598
    GGCCUUUCACUACUCCUACTT
    AGUAGGAGUAGUGAAAGGCCTT
    4-C- Aminomethyl-2-O-Methylribose
    0
    17
    0
    Sugar
    0
    93 percent target mRNA inhibition
    22372696
    SM4599
    GGCCUUUCACUACUCCUACUT
    AGUAGGAGUAGUGAAAGGCCTT
    4-C- Aminomethyl-2-O-Methylribose
    0
    17,20
    0
    Sugar
    0
    98 percent target mRNA inhibition
    22372696
    SM4602
    GGCCUUUCACUACUCCUACTT
    AGUAGGAGUAGUGAAAGGCCUT
    4-C- Aminomethyl-2-O-Methylribose
    0
    19
    0
    Sugar
    0
    96 percent target mRNA inhibition
    22372696
    SM4603
    GGCCUUUCACUACUCCUACTT
    AGUAGGAGUAGUGAAAGGCCTT
    4-C- Aminomethyl-2-O-Methylribose
    0
    5,7
    0
    Sugar
    0
    96 percent target mRNA inhibition
    22372696
    SM4609
    GGCCUUUCACUACUCCUACGA
    GUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    NA
    22494497
    SM4610
    CUGGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    Palmitic acid
    0
    1
    0
    Phosphate
    0
    NA
    22494497