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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 0 are 558
    Results from 225 - 250
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3067
    TCCAGAACAAAGGAAACGGTT
    CCGUUUCCUUUGUUCUGGATT
    Locked nucleic acid
    0
    1,20,21
    0
    Sugar
    0
    50 percent target mRNA inhibition
    15653644
    SM3091
    GCUUGAAGUCUUUAAUUAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoro-4-Thioarabinonucleic acid
    0
    16,17
    0
    Sugar
    0
    IC-50 = 0.1 nM for target mRNA
    17284457
    SM3092
    GCUUGAAGUCUUUAATTAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    16,17
    0
    Sugar
    0
    IC-50 = 0.2 nM for target mRNA
    17284457
    SM3101
    GCTTGAAGTCTTTAATTAAGG
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21
    0
    Sugar
    0
    IC-50 = 7.8 nM for target mRNA
    17284457
    SM3102
    GCTTGAAGTCTTTAATTAATT
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,20,21
    0
    Sugar
    0
    IC-50 = 2.4 nM for target mRNA
    17284457
    SM3103
    GCTTGAAGTCTTTATTAAA
    UUAAUUAAAGACUUCAAGCGG
    2-Deoxy-2-Fluoroarabinonucleic acid
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    IC-50 (Greater than 20 nM) for target mRNA
    17284457
    SM3126
    ACCUGACGUUGUACAAAUUTT
    AAUATTTGTACAACGTCAGGT
    4-Methylbenzimidazole
    0
    13
    0
    Base
    0
    75 percent target mRNA inhibition
    18624291
    SM3127
    ACCUGACGUUGUACAAAUUTT
    AAAUUUUGUACAACGUCAGGU
    2,4-Difluorotoluene
    0
    18
    0
    Base
    0
    18 percent target mRNA inhibition
    18624291
    SM3128
    ACCUGACGUAGUUCAAAUUTT
    AAAAUUUGUACUACGUCAGGU
    2,4-Difluorotoluene
    0
    19
    0
    Base
    0
    98 percent target mRNA inhibition
    18624291
    SM3135
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    91 percent target mRNA inhibition
    18637735
    SM3136
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    92 percent target mRNA inhibition
    18637735
    SM3139
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    88 percent target mRNA inhibition
    18637735
    SM3153
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    95 percent target mRNA inhibition
    18637735
    SM3154
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    85 percent target mRNA inhibition
    18637735
    SM3157
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18637735
    SM3171
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    66 percent target mRNA inhibition
    18637735
    SM3172
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-O-Methyl
    0
    1,3,6,7,8,9,12,13,15,16,17,18
    0
    Sugar
    0
    40 percent target mRNA inhibition
    18637735
    SM3175
    GCACCAGAGCCAAUGGAACUUGATG
    CAUCAAGUUCCAUUGGCUCUGGUGCUU
    2-Fluoro
    0
    2,4,5,10,11,14,19,20
    0
    Sugar
    0
    55 percent target mRNA inhibition
    18637735
    SM3185
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    31 percent target mRNA inhibition
    18637735
    SM3191
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3197
    ACCCUGAAGUUCAUCUGCACCACCG
    CGGUGGUGCAGAUGAACUUCAGGGUCA
    2-O-Methyl
    0
    2,4,6,8,10,12,14,16,18
    0
    Sugar
    0
    97 percent target mRNA inhibition
    18637735
    SM3231
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    20,21
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18776474
    SM3232
    GCAGCACGACUUCTTCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    13,14,15,16,20,21
    0
    Sugar
    0
    90 percent target mRNA inhibition
    18776474
    SM3233
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    2,5,7,20,21
    0
    Sugar
    0
    79 percent target mRNA inhibition
    18776474
    SM3236
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    Tricyclodeoxyribonucleic acid
    0
    20,21
    0
    Sugar
    0
    85 percent target mRNA inhibition
    21687522