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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxythymidine are 67
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2332
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    82 percent target mRNA inhibition
    17539595
    SM2338
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    Aminoisonucleotide-Adenine* 2-Deoxythymidine
    20,21
    1* 20,21
    Sugar
    Base; Sugar
    39 percent target mRNA inhibition
    17539595
    SM2339
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    Aminoisonucleotide-Adenine* 2-Deoxythymidine
    20,21
    18* 20,21
    Sugar
    Base; Sugar
    50 percent target mRNA inhibition
    17539595
    SM2340
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    Aminoisonucleotide-Adenine* 2-Deoxythymidine
    20,21
    8* 20,21
    Sugar
    Base; Sugar
    2 percent target mRNA inhibition
    17539595
    SM2341
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    Aminoisonucleotide-thymidine* Aminoisonucleotide-adenine* 2-Deoxythymidine
    20,21
    1* 20* 21
    Sugar
    Base; Sugar
    13 percent target mRNA inhibition
    17539595
    SM2342
    CUGGUAAAGCAUUCAGUAUTT
    AUACUGAAUGCUUUACCAGTT
    2-Deoxythymidine
    Aminoisonucleotide-thymidine* Aminoisonucleotide-adenine* 2-Deoxythymidine
    20,21
    1,20* 8,15 * 21
    Sugar
    Base; Sugar
    0 percent target mRNA inhibition
    17539595
    SM2391
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    2-Deoxythymidine
    0
    20,21
    Sugar
    Sugar
    40 percent target mRNA inhibition
    23682837
    SM2400
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    D-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    1* 20,21
    Sugar
    Nucleoside
    63 percent target mRNA inhibition
    23682837
    SM2401
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    L-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    1* 20,21
    Sugar
    Nucleoside
    63 percent target mRNA inhibition
    23682837
    SM2402
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    D-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    4* 20,21
    Sugar
    Nucleoside
    31 percent target mRNA inhibition
    23682837
    SM2403
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    L-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    4* 20,21
    Sugar
    Nucleoside
    40 percent target mRNA inhibition
    23682837
    SM2404
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    D-Isonucleoside uracil* 2-Deoxythymidine
    20,21
    5* 20,21
    Sugar
    Nucleoside
    27 percent target mRNA inhibition
    23682837
    SM2405
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    L-Isonucleoside uracil* 2-Deoxythymidine
    20,21
    5* 20,21
    Sugar
    Nucleoside
    0 percent target mRNA inhibition
    23682837
    SM2406
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    D-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    11* 20,21
    Sugar
    Nucleoside
    4 percent target mRNA inhibition
    23682837
    SM2407
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    L-Isonucleoside adenosine* 2-Deoxythymidine
    20,21
    11* 20,21
    Sugar
    Nucleoside
    29 percent target mRNA inhibition
    23682837
    SM2408
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    D-Isonucleoside uracil* 2-Deoxythymidine
    20,21
    12* 20,21
    Sugar
    Nucleoside
    26 percent target mRNA inhibition
    23682837
    SM2409
    GCAACUCAUGGUUCAUGCUTT
    AGCAUGAACCAUGAGUUGCTT
    2-Deoxythymidine
    L-Isonucleoside uracil* 2-Deoxythymidine
    20,21
    12* 20,21
    Sugar
    Nucleoside
    0 percent target mRNA inhibition
    23682837
    SM2493
    CGUUAGCAGAAACAAAAGGAGTT
    CUCCUUUUGUUUCUGCUAACGTT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2499
    TTCGUUAGCAGAAACAAAAGGAG
    TTCUCCUUUUGUUUCUGCUAACG
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2501
    UGGAAUGAACCACUGGAAUUUTT
    AAAUUCCAGUGGUUCAUUCCATT
    2-Deoxythymidine
    2-Deoxythymidine
    22,23
    22,23
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2504
    TTUGGAAUGAACCACUGGAAUUU
    TTAAAUUCCAGUGGUUCAUUCCA
    2-Deoxythymidine
    2-Deoxythymidine
    1,2
    1,2
    Sugar
    Sugar
    High target mRNA inhibition efficacy
    12771196
    SM2534
    UCUUGAUGUACUCCCCUCG
    CGAGGGGAGUACAUCAAGA
    2-Deoxythymidine
    0
    1,2
    0
    Sugar
    0
    NA
    12771196
    SM4219
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    2-Deoxythymidine
    20,21
    20,21
    Sugar
    Sugar
    94 percent target mRNA inhibition
    22895883
    SM4222
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside thymidine* 2-Deoxythymidine
    20,21
    4 * 20,21
    Sugar
    Sugar ; Sugar
    69 percent target mRNA inhibition
    22895883
    SM4223
    UCGGGAAAUUUCUCUAUUATT
    UAAUAGAGAAAUUUCCCGATT
    2-Deoxythymidine
    L-isonucleoside adenosine* 2-Deoxythymidine
    20,21
    19 * 20,21
    Sugar
    Sugar ; Sugar
    90 percent target mRNA inhibition
    22895883