| ASPsiRNA ID | Pairing of target region (top) and ASP-siRNA (bottom) | Efficacy (mut)(%) | Efficacy (wt) (%) | Diff | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|---|
| ASPsiRNA ID | Mutant allele/ASP-siRNA | Efficacy for mutant(%) |
Efficacy for wild (%) |
Relative Difference (%) | Gene | Disease | Mutation | RefSNP | Analysis | Pubmed ID |
| aspsirna0059 | AGUGAAUCUGGAUGCAGAAU UCACUUAGACCUACGUCUUA |
NA | NA | NA | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 | 
|
|
| aspsirna0060 | AAGUGAAUCUGGAUGCAGAA UUCACUUAGACCUACGUCUU |
20 | 83 | -63 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0061 | GAAGUGAAUCUGGAUGCAGA CUUCACUUAGACCUACGUCU |
42 | 90 | -48 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0062 | UGAAGUGAAUCUGGAUGCAG ACUUCACUUAGACCUACGUC |
28 | 64 | -36 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0063 | CUGAAGUGAAUCUGGAUGCA GACUUCACUUAGACCUACGU |
44 | 79 | -35 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0064 | UCUGAAGUGAAUCUGGAUGC AGACUUCACUUAGACCUACG |
9 | 16 | -7 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0065 | AGUGAUCAUCAUCACCUUG UCACUAGUAGUAGUGGAAC |
3 | 17 | -14 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0066 | CAGUGAUCAUCAUCACCUU GUCACUAGUAGUAGUGGAA |
36 | 63 | -27 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0067 | ACAGUGAUCAUCAUCACCU UGUCACUAGUAGUAGUGGA |
18 | 17 | 1 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0068 | GACAGUGAUCAUCAUCACC CUGUCACUAGUAGUAGUGG |
0 | 3 | -3 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0069 | CGACAGUGAUCAUCAUCAC GCUGUCACUAGUAGUAGUG |
45 | 55 | -10 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0070 | AGUGAUCUUCAUCACCUUG UCACUAGAAGUAGUGGAAC |
10 | 16 | -6 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0071 | CAGUGAUCUUCAUCACCUU GUCACUAGAAGUAGUGGAA |
13 | 73 | -60 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0072 | ACAGUGAUCUUCAUCACCU UGUCACUAGAAGUAGUGGA |
7 | 43 | -36 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0073 | GACAGUGAUCUUCAUCACC CUGUCACUAGAAGUAGUGG |
2 | 0 | 2 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0074 | CGACAGUGAUCUUCAUCAC GCUGUCACUAGAAGUAGUG |
14 | 60 | -46 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0075 | GUGAUCGGCAUCACCUUGG CACUAGCCGUAGUGGAACC |
12 | 8 | 4 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0076 | AGUGAUCGGCAUCACCUUG UCACUAGCCGUAGUGGAAC |
10 | 20 | -10 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0077 | CAGUGAUCGGCAUCACCUU GUCACUAGCCGUAGUGGAA |
45 | 35 | 10 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0078 | ACAGUGAUCGGCAUCACCU UGUCACUAGCCGUAGUGGA |
16 | 4 | 12 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0079 | GACAGUGAUCGGCAUCACC CUGUCACUAGCCGUAGUGG |
18 | 1 | 17 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0169 | UGAAGUGAAUCUGGAUGCAG ACUUCACUUAGACCUACGUC |
84 | 12 | 72 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0170 | UGAAGUGAAUCUGGAUGCAG ACUUCACUUAGACCUACGUC |
60 | 10 | 50 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0190 | UGAAGUGAAGAUGGAUGCAG ACUUCACUUCUACCUACGUC |
83 | Poor efficacy | High discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0191 | AAGUGAAGAUGGAUGCAGAAUUC UUCACUUCUACCUACGUCUUAAG |
NA | NA | NA | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0192 | AAGUGAAUCUGGAUGCAGAA UUCACUUAGACCUACGUCUU |
12 | Poor efficacy | Lowest discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0193 | GAAGUGAAUCUGGAUGCAGA CUUCACUUAGACCUACGUCU |
65 | Poor efficacy | High discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0194 | UGAAGUGAAUCUGGAUGCAG ACUUCACUUAGACCUACGUC |
0 | Poor efficacy | Lowest discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0195 | CUGAAGUGAAUCUGGAUGCA GACUUCACUUAGACCUACGU |
45 | Poor efficacy | Moderate discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0196 | UCUGAAGUGAAUCUGGAUGC AGACUUCACUUAGACCUACG |
84 | 82 | 2 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0428 | GUGGUUGGUAAAGCCUCAG CACCAACCAUUUCGGAGUC |
63 | 93 | -30 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0429 | UGUGGUUGGUAAAGCCUCA ACACCAACCAUUUCGGAGU |
53 | 8 | 45 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0430 | UUGUGGUUGGUAAAGCCUC AACACCAACCAUUUCGGAG |
54 | 28 | 26 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0431 | GUUGUGGUUGGUAAAGCCU CAACACCAACCAUUUCGGA |
72 | 28 | 44 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0432 | UGUUGUGGUUGGUAAAGCC ACAACACCAACCAUUUCGG |
38 | 14 | 24 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0433 | GUGUUGUGGUUGGUAAAGC CACAACACCAACCAUUUCG |
90 | 15 | 75 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0434 | AGUGUUGUGGUUGGUAAAG UCACAACACCAACCAUUUC |
73 | 40 | 33 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0435 | CAGUGUUGUGGUUGGUAAA GUCACAACACCAACCAUUU |
69 | 29 | 40 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0436 | ACAGUGUUGUGGUUGGUAA UGUCACAACACCAACCAUU |
63 | 17 | 46 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0437 | UACAGUGUUGUGGUUGGUA AUGUCACAACACCAACCAU |
65 | 7 | 58 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0438 | CUACAGUGUUGUGGUUGGU GAUGUCACAACACCAACCA |
0 | 0 | 0 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0439 | UCUACAGUGUUGUGGUUGG AGAUGUCACAACACCAACC |
0 | 0 | 0 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0440 | UUCUACAGUGUUGUGGUUG AAGAUGUCACAACACCAAC |
37 | 0 | 37 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0441 | UUUCUACAGUGUUGUGGUU AAAGAUGUCACAACACCAA |
15 | 0 | 15 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0442 | UUUUCUACAGUGUUGUGGU AAAAGAUGUCACAACACCA |
83 | 0 | 83 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0443 | AUUUUCUACAGUGUUGUGG UAAAAGAUGUCACAACACC |
6 | 0 | 6 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0444 | CAUUUUCUACAGUGUUGUG GUAAAAGAUGUCACAACAC |
82 | 0 | 82 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0445 | UCAUUUUCUACAGUGUUGU AGUAAAAGAUGUCACAACA |
80 | 22 | 58 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0446 | UUCAUUUUCUACAGUGUUG AAGUAAAAGAUGUCACAAC |
70 | 0 | 70 | PSEN1 | Alzheimers disease | c.811C>G, p.Leu271Val | rs63750886 |
|
|
| aspsirna0565 | AAUCUGGAUGCAGAAUUCCGA UUAGACCUACGUCUUAAGGCU |
0 | 0 | High discrimination | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0566 | AAGUGAAUCUGGAUGCAGAAU UUCACUUAGACCUACGUCUUA |
0 | 3 | -3 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0567 | UGAAGUGAAUCUGGAUGCA ACUUCACUUAGACCUACGU |
3 | 70 | -67 | APP | Alzheimers disease | c.2010_2011delGAinsTC (p.Lys670_Met671delinsAsnLeu) | rs28186516 |
|
|
| aspsirna0568 | GCGACAGUGAUCAUCAUCACCU CGCUGUCACUAGUAGUAGUGGA |
10 | 60 | -50 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0569 | GACAGUGAUCAUCAUCACCUU CUGUCACUAGUAGUAGUGGAA |
64 | 67 | -3 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0570 | ACAGUGAUCAUCAUCACCUUG UGUCACUAGUAGUAGUGGAAC |
73 | 68 | 5 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0571 | CAGUGAUCAUCAUCACCUUGG GUCACUAGUAGUAGUGGAACC |
38 | 77 | -39 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0572 | CGACAGUGAUCAUCAUCACCU GCUGUCACUAGUAGUAGUGGA |
90 | 70 | 20 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0573 | CGCGACAGUGAUCAUCAUCACCUUG GCGCUGUCACUAGUAGUAGUGGAAC |
20 | 58 | -38 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0574 | GGACAGUCAUCAUCAUCACCUU CCUGUCAGUAGUAGUAGUGGAA |
29 | 75 | -46 | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0575 | GGACUGUGAUCAUCAUCACCU CCUGACACUAGUAGUAGUGGA |
78 | Moderately effective | Poor discrimination | APP | Alzheimers disease | c.2149G>A,p.Val717Ile | rs63750264 |
|
|
| aspsirna0872 | GUCCCGGCAGGUGGUGGAGC CAGGGCCGUCCACCACCUCG |
60 | 15 | 45 | PSEN1 | Alzheimers disease | c.458C>G, p.Leu153Val | 63751441 |
|
|
| aspsirna0873 | GACCCGGCAGGUGGUGGAGCA CUGGGCCGUCCACCACCUCGU |
70 | 20 | 50 | PSEN1 | Alzheimers disease | c.458C>G, p.Leu153Val | 63751441 |
|
|
| aspsirna0874 | GUCCCGGCAGGUGGUGGAGC CAGGGCCGUCCACCACCUCG |
70 | 10 | 60 | PSEN1 | Alzheimers disease | c.458C>G, p.Leu153Val | 63751441 |
|
|
| aspsirna0875 | GACCCGGCAGGUGGUGGAGCA CUGGGCCGUCCACCACCUCGU |
80 | 20 | 60 | PSEN1 | Alzheimers disease | c.458C>G, p.Leu153Val | 63751441 |
|