A database of FDA approved therapeutic peptides and proteins
ID | ThPPID | Name | Peptide Sequence | Length | Functional Classification | Disease | Brand | Company | Physical Appearance | Route of Administartion | Category | Target |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1001 | Th1001 | Lepirudin | LVYTDCTESGQNLCLCEGSN Full view | 65 | Ia | Hematological,Metabolic | Refludan | Berlex Labs | Sterile, white, freeze-dried powder | Intravenous infusion | Antithrombins and Fibrinolytic Agents | Prothrombin |
1025 | Th1004 | Denileukin diftitox | MGADDVVDSSKSFVMENFSS Full view | 255 | IIb | Cancer | Ontak | Seragen Inc | Sterile, white, preservative-free, lyophilized powder. | Intravenous(IV) administration | Antineoplastic Agents | Interleukin-2 receptor subunit alpha,Interleukin-2 receptor subunit beta,Cytokine receptor common subunit gamma |
1028 | Th1005 | Etanercept | LPAQVAFTPYAPEPGSTCRL Full view | 255 | IIa | Immunological | Enbrel | Immunex Corp | Lyophilized powder. | Subcutaneous injection | Immunosuppressive Agents | Tumor necrosis factor,Tumor necrosis factor receptor superfamily member 1B,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c,Lymphotoxin-alpha,Low affinity immunoglobulin gamma Fc region re |
1033 | Th1006 | Bivalirudin | FPRPGGGGNGDFEEIPEEYL Full view | 20 | Ia | Hematological,Metabolic | Angiox | The Medicines Company UK Ltd | Powder for concentrate for solution | Injection | Antithrombins | Prothrombin |
1055 | Th1009 | Alteplase | SYQVICRDEKTQMIYQQHQS Full view | 255 | Ib | Hematological,Metabolic | Activase | Genentech Inc | Sterile, white to off-white, lyophilized powder | Intravenous | Thrombolytic Agents | Plasminogen,Fibrinogen alpha chain,Urokinase plasminogen activator surface receptor,Plasminogen activator inhibitor 1 |
1067 | Th1012 | Reteplase | SYQGNSDCYFGNGSAYRGTH Full view | 255 | Ib | Hematological,Metabolic | Retavase | Centocor | Sterile, white, lyophilized powder | Intravenous Injection | Fibrinolytic Agents, Thrombolytic agents | Plasminogen,Fibrinogen alpha chain,Urokinase plasminogen activator surface receptor,Plasminogen activator inhibitor 1 |
1077 | Th1013 | Epoetin alfa | APPRLICDSRVLERYLLEAK Full view | 166 | Ib | Hematological | Nanokine | Nanogen Pharmaceutical biotechnology, Vietnam) | Sterile, white, lyophilized powder. The reconstituted preparation with 1 ml solvent (containing 0.9% benzyl alcohol) results in a clear, colorless solution. | Injection | Anti-anemic Agents, Hematinics | Erythropoietin receptor |
1121 | Th1017 | Sargramostim | APARSPSPSTQPWEHVNAIQ Full view | 127 | Ib | Immunological | Leukine | Berlex Laboratories Inc | Sterile, preserved (1.1% benzyl alcohol), injectable solution (500 mcg/mL) and also as sterile, white, preservative free lyophilized powder (250 mcg) that requires reconstitution with 1 mL sterile water for Injection | Subcutaneous Injection (SC) or Intravenous infusion (IV) | Immunosuppressive Agents | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,Interleukin-3 receptor subunit alpha,Cytokine receptor common subunit beta,Syndecan-2,Bone marrow proteoglycan |
1129 | Th1018 | Secretin | HSDGTFTSELSRLRDSARLQ Full view | 27 | IV | Hormonal disorders | SecreFlo | Repligen Corp | Lyophilized white powder | Intravenous infusion | Diagnostic Agents | Secretin receptor |
1135 | Th1019 | Peginterferon alfa-2b | CDLPQTHSLGSRRTLMLLAQ Full view | 165 | Ib | Immunological | PEG-Intron | Schering Corp | Powder | Subcutaneous injection | Immunosuppressive Agents | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1136 | Th1019 | Peginterferon alfa-2b | CDLPQTHSLGSRRTLMLLAQ Full view | 165 | Ib | Immunological | Unitron PEG | N.A. | Lyophilized powder | Subcutaneous injection | Immunosuppressive Agents | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1142 | Th1020 | Asparaginase | QMSLQQELRYIEALSAIVET Full view | 255 | Ic | Cancer | Elspar | Merck & Co. Inc | Lyophilized plug or powder | Intravenous or Intramuscular. Intravenous method dose has higher risk of allergic reaction, so often a test dose is given first. | Antineoplastic Agents | L-asparagine |
1145 | Th1021 | Thyrotropin Alfa | Alpha chain:APDVQDC< Full view | 204 | IV | Cancer | Thyrogen | Genzyme Inc | Lyophilized powder | Intramuscular preferably the buttocks | Diagnostic Agents | Thyrotropin receptor |
1148 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Advate | N.A. | Powder form | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1149 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Alphanate | N.A. | Lyophilized powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1150 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Bioclate | Baxter Healthcare Corporation, Hyland Division and Genetics Institute, Inc. | Sterile, nonpyrogenic, off-white to faint yellow, lyophilized powder | Intravenous infusion | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1153 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Hyate:C | N.A. | Powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1154 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Koate-HP | N.A. | Powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1155 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Kogenate FS | N.A. | Powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1156 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Monarc-M | N.A. | Powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1157 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Monoclate-P | N.A. | Lyophilized powder for solution | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1158 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | ReFacto | N.A. | Lyophilized powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1159 | Th1022 | Antihemophilic Factor | ATRRYYLGAVELSWDYMQSD Full view | 255 | Ia | Hematological,Metabolic | Xyntha | N.A. | Sterile, nonpyrogenic, preservative-free, freeze-dried powder | Intravenous Injection | Coagulants and Thrombotic agents | Coagulation factor X,Coagulation factor IX,von Willebrand factor,Phytanoyl-CoA dioxygenase, peroxisomal,Asialoglycoprotein receptor 2,78 kDa glucose-regulated protein,Calreticulin,Calnexin,Protein ERGIC-53,Prolow-density lipoprotein receptor-related protein 1,Multiple coagulation factor deficiency protein 2 |
1201 | Th1026 | Anistreplase | SYQVICRDEKTQMIYQQHQS Full view | 255 | Ic | Hematological,Metabolic | Eminase | Wulfing Pharma GmbH | Dry powder | Intravenous infusion | Thrombolytic Agents, Fibrinolytic agents | Plasminogen,Fibrinogen alpha chain,Urokinase plasminogen activator surface receptor,Plasminogen activator inhibitor 1 |
1210 | Th1028 | Tenecteplase | SYQVICRDEKTQMIYQQHQS Full view | 255 | Ib | Hematological,Metabolic | TNKase | Genentech Inc | Sterile, white to off-white, lyophilized powder | Intravenous Injection | Thrombolytic Agents, Fibrinolytic agents | Plasminogen,Fibrinogen alpha chain,Urokinase plasminogen activator surface receptor,Plasminogen activator inhibitor 1,Plasminogen activator inhibitor 2,Tetranectin,Keratin, type II cytoskeletal 8,Annexin A2,Calreticulin,Calnexin,Prolow-density lipoprotein |
1215 | Th1029 | Menotropins | Alpha-Chain(LH):APD< Full view | 222 | Ib | Hormonal disorders | Menopur | N.A. | Sterile, lyophilized powder which is reconstitution with sterile 0.9% Sodium Chloride Injection. | Subcutaneous Injection | Fertility Agents | Follicle-stimulating hormone receptor,Lutropin-choriogonadotropic hormone receptor |
1234 | Th1032 | Coagulation factor VIIa | ANAFLEELRPGSLERECKEE Full view | 255 | Ib | Hematological,Metabolic | NovoSeven | Novo Nordisk | Sterile, white lyophilized powder | Injection | Thrombotic Agents, Coagulants | Coagulation factor X,Serine protease hepsin,Tissue factor pathway inhibitor,Vitamin K-dependent gamma-carboxylase,Coagulation factor VII,Tissue factor |
1242 | Th1033 | Oprelvekin | GPPPGPPRVSPDPRAELDST Full view | 177 | Ib | Cancer/Haemetological | Neumega | Genetics Institute Inc | Sterile, lyophilized powder | Subcutaneous injection | Coagulants and Thrombotic Agents, Anti-neoplastic agents | Interleukin-11 receptor subunit alpha |
1246 | Th1034 | Palifermin | SYDYMEGGDIRVRRLFCRTQ Full view | 140 | Ib | Cancer | Kepivance | Amgen Inc | Sterile, lyophilized powder | Intravenous infusion | Anti-Mucositis Agents | Fibroblast growth factor receptor 2,Neuropilin-1,Fibroblast growth factor receptor 1,Fibroblast growth factor receptor 4,Fibroblast growth factor receptor 3,Basement membrane-specific heparan sulfate proteoglycan core protein |
1252 | Th1035 | Glucagon recombinant | HSQGTFTSDYSKYLDSRRAQ Full view | 29 | IV | Hormonal/Metabolic/genetic | GlucaGen | Novo Nordisk | Sterile, lyophilized white powder | Subcutaneous, Intramuscular, or Intravenous infusion | Hypoglycemic Agents | Glucagon receptor,Glucagon-like peptide 2 receptor,Glucagon-like peptide 1 receptor |
1253 | Th1035 | Glucagon recombinant | HSQGTFTSDYSKYLDSRRAQ Full view | 29 | IV | Hormonal/Metabolic/genetic | Glucagon | Eli Lilly | Powder | Subcutaneously or Intramuscularly Injection | Hypoglycemic Agents | Glucagon receptor,Glucagon-like peptide 2 receptor,Glucagon-like peptide 1 receptor |
1290 | Th1042 | Collagenase | MKRKCLSKRLMLAITMATIF Full view | 255 | Ic | Hematological | Xiaflex | Auxilium | Sterile lyophilized powder (white cake) | Intralesional Injection | N.A. | Collagen alpha-1(I) chain,Collagen alpha-1(II) chain,Collagen alpha-1(III) chain,Collagen alpha-2(I) chain |
1305 | Th1043 | Rasburicase | SAVKAARYGKDNVRVYKVHK Full view | 255 | Ic | Metabolic/Genetic | Elitek | Sanofi-Synthelabo Inc | Sterile, white to off-white, lyophilized powder | Intravenous administration | Antihyperuricemic Agents, Gout suppressants | Uric acid |
1306 | Th1043 | Rasburicase | SAVKAARYGKDNVRVYKVHK Full view | 255 | Ic | Metabolic/Genetic | Fasturtec | N.A. | Powder and solvent that are made upto make solution. | Intravenous administartion | Antihyperuricemic Agents, Gout suppressants | Uric acid |
1331 | Th1047 | Alpha-1-proteinase inhibitor | EDPQGDAAQKTDTSHHDQDH Full view | 255 | IIa | Metabolic/Geneti/Respiratory | Aralast | Baxter | Lyophilized powder | Intravenous infusion | Serine Proteinase Inhibitors, Enzyme replacement agents, trypsin inhibitors | Neutrophil elastase |
1332 | Th1047 | Alpha-1-proteinase inhibitor | EDPQGDAAQKTDTSHHDQDH Full view | 255 | IIa | Metabolic/Geneti/Respiratory | Prolastin | Talecris Biotherapeutics C formerly Bayer | Lyophilized powder | Intravenous infusion | Serine Proteinase Inhibitors, Enzyme replacement agents, trypsin inhibitors | Neutrophil elastase |
1341 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Avonex | Biogen Inc | Lyophilized powder vial, Sterile liquid as single used prefilled syringe and also available as single use prefilled autoinjector. | Intramuscular Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1342 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Betaferon | Bayer | Powder and solvent that are made upto make solution. | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1343 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Betaseron | Merck | Sterile, white to off-white powder | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1345 | Th1049 | Interferon beta-1a | MSYNLLGFLQRSSNFQCQKL Full view | 166 | Ib | Cancer/Infectious/Immunological | Extavia | Novartis | Sterile, white to off-white powder | Subcutaneous Injection | Immunosuppressive Agents, Antineoplastic, Antiviral, Immunologic factors | Interferon alpha/beta receptor 1,Interferon alpha/beta receptor 2 |
1368 | Th1054 | Infliximab | N.A. Full view | 0 | IIa | Immunological | REMICADE | Centocor Inc | Sterile, white, lyophilized powder, following reconstitution with 10 mL of Sterile Water for Injection, USP, the resulting pH is approximately 7.2. | Intravenous infusion | Antirheumatic Agents, Anti-Inflammatory Agents, Non-Steroidal, Dermatologic Agents, Gastrointestinal Agents and Immunosuppressive Agents | Tumor necrosis factor |
1376 | Th1057 | Interferon beta-1b | MSYNLLGFLQRSSNFQSQKL Full view | 166 | Ib | Immunological | Betaseron | Bayer | Sterile, white to off-white powder | Subcutaneous Injection | Adjuvants, Immunologic and Immunosuppressive Agents | N.A. |
1377 | Th1057 | Interferon beta-1b | MSYNLLGFLQRSSNFQSQKL Full view | 166 | Ib | Immunological | Betaferon | Bayer | Powder and solvent that are made upto make solution. | Subcutaneous Injection | Adjuvants, Immunologic and Immunosuppressive Agents | N.A. |
1378 | Th1057 | Interferon beta-1b | MSYNLLGFLQRSSNFQSQKL Full view | 166 | Ib | Immunological | Extavia | Novartis | Sterile, white to off-white powder | Subcutaneous Injection | Adjuvants, Immunologic and Immunosuppressive Agents | N.A. |
1385 | Th1061 | Trastuzumab | Light chain 1: DIQMT Full view | 1364 | IIa | Cancer | Herceptin | Genentech | Sterile, white to pale yellow, preservative-free lyophilized powder |  Intravenous administration | Antineoplastic Agents | Insulin receptor,Insulin-like growth factor 1 receptor,Insulin-degrading enzyme,HLA class II histocompatibility antigen, DQ alpha 2 chain,HLA class II histocompatibility antigen, DQ beta 1 chain,Retinoblastoma-associated protein,Cathepsin D,Carboxypeptidase E,Neuroendocrine convertase 2,Neuroendocrine convertase 1,Protein NOV homolog,Low-density lipoprotein receptor-related protein 2,Insulin-like growth factor-binding protein 7,Synaptotagmin-like protein 4 |
1403 | Th1065 | Digoxin Immune Fab (Ovine) | Heavy Chain: EVQLQQS Full view | 438 | IIa | Cardiac | DIGIBIND | Galaxo Smith Kline | Sterile lyophilized powder of antigen binding fragments (Fab) derived from specific antidigoxin antibodies raised in sheep. | Intravenous infusion after reconstitution with Sterile Water for Injection | Antidotes | T-cell surface glycoprotein CD3 delta chain, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface glycoprotein CD3 gamma chain, T-cell surface glycoprotein CD3 zeta chain, Low affinity immunoglobulin gamma Fc region receptor III-B, Complement C1r subcomponent, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, Low affinity immunoglobulin gamma Fc region receptor III-A, Complement C1s subcomponent, High affinity immunoglobulin gamma Fc receptor I, Low affinity immunoglobulin gamma Fc region receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-c |
1415 | Th1069 | Pegvisomant | FPTIPLSRLFDNAMLRAHRL Full view | 191 | IIa | Hormonal | SOMAVERT | Pfizer | Sterile, white lyophilized powder | Subcutaneous Injection | Hormone Replacement Agents | B-lymphocyte antigen CD20,Low affinity immunoglobulin gamma Fc region receptor III-B,Complement C1r subcomponent,Complement C1q subcomponent subunit A,Complement C1q subcomponent subunit B,Complement C1q subcomponent subunit C,Low affinity immunoglobulin gamma Fc region receptor III-A,High affinity immunoglobulin gamma Fc receptor I,Low affinity immunoglobulin gamma Fc region receptor II-a,Low affinity immunoglobulin gamma Fc region receptor II-b,Low affinity immunoglobulin gamma Fc region receptor II-c |
1421 | Th1070 | Botulinum Toxin Type A | MPFVNKQFNYKDPVNGVDIA Full view | 1296 | Ic | Neurological Disorder | Xeomin | MERZ AESTHETICS | Sterile white to off-white lyophilized powder after reconstitution with preservative-free 0.9% Saline for Injection. | Intramuscular Injection | Neuromuscular Blocking Agents, Anti-Wrinkle Agents and Antidystonic Agents | Growth hormone receptor |
1423 | Th1071 | Pancrelipase | Pancreatic alpha amy Full view | 1206 | Ia | Metabolic/genetic/ | Viokace | Aptalis Pharma US, Inc. | Beige-white amorphous powder, miscible in water and practically insoluble in alcohol and converted to tablet form | Oral route | Gastrointestinal Agents and Enzyme Replacement Agents | Synaptosomal-associated protein 25,Rho-related GTP-binding protein RhoB, Dietary fat,Dietary protein,Dietary starch |
1424 | Th1071 | Pancrelipase | Pancreatic alpha amy Full view | 1206 | Ia | Metabolic/genetic/ | ULTRESA | Aptalis Pharma US, Inc. | Beige-white amorphous powder, miscible in water and practically insoluble or insoluble in alcohol and ether and converted to Delayed-Release Capsules | Oral route | Gastrointestinal Agents and Enzyme Replacement Agents | Synaptosomal-associated protein 25,Rho-related GTP-binding protein RhoB, Dietary fat,Dietary protein,Dietary starch |